{"id":"W1993428746","doi":"10.1016/j.regpep.2007.03.007","title":"Elevated renal norepinephrine in proANP gene-disrupted mice is associated with increased tyrosine hydroxylase expression in sympathetic ganglia","year":2007,"lang":"en","type":"article","venue":"Regulatory Peptides","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Tyrosine hydroxylase; Atrial natriuretic peptide; Sympatholytic; Catecholamine; Kidney; Sympathetic nervous system; Tyrosine 3-Monooxygenase; Norepinephrine; Medicine; Blood pressure; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007638437,0.0003391465,0.00052761,0.0005291777,0.00005864743,0.00001641136,0.00009103537,0.0001639652,0.0001363879],"category_scores_gemma":[0.000105698,0.0002654552,0.00008278753,0.0007715216,0.00008508227,0.0001355762,0.00005303751,0.0002254459,0.00003394873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004550084,"about_ca_system_score_gemma":0.0001048566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001990748,"about_ca_topic_score_gemma":0.000681694,"domain_scores_codex":[0.997786,0.0000961516,0.0005548894,0.0005019783,0.0004733749,0.0005876041],"domain_scores_gemma":[0.9989816,0.00007781853,0.0001572581,0.0004467691,0.00009848057,0.0002380563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001449014,0.001881929,0.2736697,0.0001381836,0.0001738769,0.002669721,0.0009961486,0.00006391363,0.7152576,0.0000304557,0.002776247,0.0008931869],"study_design_scores_gemma":[0.009038335,0.0005280881,0.6639934,0.001645437,0.0001360556,0.00003897318,0.0001553091,0.000626552,0.3221256,0.00004366288,0.001298428,0.0003702026],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976801,0.0002176901,0.00002743696,0.0004801452,0.00002339408,0.001086386,0.000009030081,0.0001513665,0.0003244162],"genre_scores_gemma":[0.9964177,0.00001470971,0.001518862,0.000426625,0.00006246897,0.0000553096,0.0002036993,0.00005606046,0.001244556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.393132,"threshold_uncertainty_score":0.9999798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129948279256991,"score_gpt":0.2447344143810277,"score_spread":0.2334349315884578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}