{"id":"W1993463141","doi":"10.1038/bjc.2014.116","title":"A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer","year":2014,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast; Eisai; Public Health Agency; National Institute for Health and Care Research; Cancer Research UK; American Society of Clinical Oncology","keywords":"Carboplatin; Decitabine; Medicine; Hypomethylating agent; Azacitidine; Oncology; Ovarian cancer; Internal medicine; Neutropenia; Chemotherapy; Cisplatin; Cancer; DNA methylation; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008779021,0.0001968221,0.0004935099,0.00009375054,0.00007456191,0.00003112266,0.000156702,0.0001256455,0.00001212669],"category_scores_gemma":[0.0003930069,0.0001607447,0.000103255,0.0003240352,0.00008634634,0.00002181999,0.00005440001,0.0002828538,5.916294e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001050036,"about_ca_system_score_gemma":0.000281417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110803,"about_ca_topic_score_gemma":0.01224856,"domain_scores_codex":[0.9977692,0.0003628525,0.0008629463,0.0002580322,0.0004910926,0.0002559259],"domain_scores_gemma":[0.9981058,0.00007546296,0.00105778,0.0001698004,0.0005089886,0.00008214818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2977108,0.003422373,0.1359324,0.0001275615,0.0005651246,0.00004363111,0.001555171,0.03222829,0.1389559,0.00002267063,0.00009164757,0.3893444],"study_design_scores_gemma":[0.5602483,0.008998151,0.298335,0.001697401,0.0001864087,0.00001266147,0.00007211514,0.00145047,0.1279046,0.00007750378,0.0005128466,0.000504458],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969594,0.001148136,0.0005152568,0.0001094066,0.0003228863,0.0007941769,0.00005002202,0.000002072972,0.00009865664],"genre_scores_gemma":[0.9988248,0.0003733725,0.0003744869,0.00003920139,0.0002571325,0.00004841512,0.00002918864,0.00003047851,0.00002287375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3888399,"threshold_uncertainty_score":0.6834986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008043018515239787,"score_gpt":0.2546705349677168,"score_spread":0.246627516452477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}