{"id":"W1993463141","doi":"10.1038/bjc.2014.116","title":"A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer","year":2014,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast; Eisai; Public Health Agency; National Institute for Health and Care Research; Cancer Research UK; American Society of Clinical Oncology","keywords":"Carboplatin; Decitabine; Medicine; Hypomethylating agent; Azacitidine; Oncology; Ovarian cancer; Internal medicine; Neutropenia; Chemotherapy; Cisplatin; Cancer; DNA methylation; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003116688,0.002677575,0.004011404,0.0006570357,0.0005552542,0.001718016,0.001628113,0.002819885,0.008749018],"category_scores_gemma":[0.003468656,0.001107701,0.001898274,0.0007031049,0.002445471,0.001746484,0.0008236459,0.00472611,0.001595689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001323358,"about_ca_system_score_gemma":0.001791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001451505,"about_ca_topic_score_gemma":0.002238879,"domain_scores_codex":[0.9986452,0.0008273546,0.00005964558,0.0002134396,0.00006577666,0.0001884597],"domain_scores_gemma":[0.9975573,0.0008526706,0.0004782029,0.0002387287,0.0001141377,0.0007590096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.985672,0.006525657,0.0002530648,0.0002187741,0.000241007,0.00002711826,0.00005202518,0.0002507427,0.002104808,0.00007643707,0.0002996273,0.004278761],"study_design_scores_gemma":[0.9409884,0.05763919,0.0004906216,0.000009365722,0.00009577146,0.00001985831,0.00001511167,0.000202782,0.0001827033,0.0001095031,0.0002391323,0.000007450871],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844846,0.001918622,0.0006983284,0.001049825,0.001225894,0.007641197,0.001052467,0.0001254475,0.001803609],"genre_scores_gemma":[0.9754338,0.001816262,0.002249482,0.001746411,0.0009270707,0.01034852,0.001550523,0.00005330575,0.005874447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008749018,"threshold_uncertainty_score":0.02926832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008043018515239787,"score_gpt":0.2546705349677168,"score_spread":0.246627516452477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}