{"id":"W1993478007","doi":"10.1021/ja061282r","title":"How an Enzyme Tames Reactive Intermediates:  Positioning of the Active-Site Components of Lysine 2,3-Aminomutase during Enzymatic Turnover As Determined by ENDOR Spectroscopy","year":2006,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Metalloenzymes and iron-sulfur proteins","field":"Energy","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Chemistry; Lysine; Active site; Radical; Stereochemistry; Substrate (aquarium); Catalysis; Catalytic cycle; Hydrogen atom; Enzyme; Photochemistry; Organic chemistry; Amino acid; Alkyl; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003232398,0.0002236109,0.0001866054,0.00009352812,0.000124857,0.0006339315,0.0004338647,0.0004610738,0.0006572235],"category_scores_gemma":[0.0003266394,0.0002348893,0.0001370757,0.00009516231,0.0003054479,0.0005069801,0.0001371034,0.0005622454,0.0003345196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003200782,"about_ca_system_score_gemma":0.0001571729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004009569,"about_ca_topic_score_gemma":0.0005016096,"domain_scores_codex":[0.9998261,0.00002355856,0.000007768039,0.00006720873,0.00004101493,0.0000343658],"domain_scores_gemma":[0.9998265,0.00004225294,0.00004563129,0.00002480429,0.00002613843,0.0000346888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000598322,0.00001321639,0.0004732413,0.00001037078,0.000004351244,0.00003092972,0.00003397782,0.00007252647,0.9975731,0.0001566723,0.00002146665,0.001550222],"study_design_scores_gemma":[0.000005046909,0.0001192672,0.002217271,0.00000217006,0.000005823895,0.0001125003,0.00003911927,0.001729209,0.9946878,0.00008968171,0.0009849473,0.000007102013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987765,0.0003356465,0.01037118,0.00008450001,0.00001847167,0.00001480272,0.00006352026,0.0001695511,0.001177231],"genre_scores_gemma":[0.9902527,0.0001878993,0.00783648,0.00005389273,0.000006014929,0.00001313055,0.0001336096,0.00005781167,0.001458475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006572235,"threshold_uncertainty_score":0.002322316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005798522845440905,"score_gpt":0.2192204672308344,"score_spread":0.2134219443853935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}