{"id":"W1993515918","doi":"10.1038/nchembio.1484","title":"Follow your lead","year":2014,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Bromodomain; Mechanism (biology); Computational biology; Kinase; Lead (geology); Chemistry; Lead compound; Biology; Biochemistry; Epigenetics; In vitro; Gene; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001231464,0.0009573108,0.001121391,0.0009718571,0.003671497,0.004556211,0.001590201,0.01669713,0.2890145],"category_scores_gemma":[0.01298308,0.0005729453,0.001063414,0.0004733785,0.001278925,0.002283946,0.002846045,0.01266944,0.2912197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001931783,"about_ca_system_score_gemma":0.002230095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002094231,"about_ca_topic_score_gemma":0.007130595,"domain_scores_codex":[0.9983175,0.000193436,0.00006705998,0.0002163788,0.0008637084,0.0003419222],"domain_scores_gemma":[0.9965922,0.0006842667,0.0001859771,0.0002093247,0.0007220005,0.001606206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001148513,0.00001210045,0.00003271969,0.00001285472,0.000002220379,0.00007876985,0.000006072672,0.00001128969,0.00005316453,0.0007376749,0.9906099,0.008431722],"study_design_scores_gemma":[0.00001617784,0.00001457864,0.0001187013,0.00004043084,0.000002891184,0.0001060483,0.0000267332,0.00004603203,0.00006663237,0.001755026,0.9977973,0.00000939844],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0005152354,0.004979981,0.001612719,0.5308109,0.1777032,0.0001886144,0.0003912912,0.001574263,0.2822238],"genre_scores_gemma":[0.002165662,0.001521874,0.0005479323,0.2716974,0.0282381,0.0001430529,0.000149506,0.0002039208,0.6953326],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2890145,"threshold_uncertainty_score":0.9668497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140919982303847,"score_gpt":0.2657429728742807,"score_spread":0.2543337730512423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}