{"id":"W1993515918","doi":"10.1038/nchembio.1484","title":"Follow your lead","year":2014,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Bromodomain; Mechanism (biology); Computational biology; Kinase; Lead (geology); Chemistry; Lead compound; Biology; Biochemistry; Epigenetics; In vitro; Gene; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.000116252,0.0004066979,0.0003995323,0.000066546,0.00004215649,0.00001910886,0.0006030476,0.008154997,0.00008596313],"category_scores_gemma":[0.0004552955,0.0003439896,0.0003063678,0.0000810797,0.0002000412,0.000001446282,0.0001932829,0.002941976,0.000126373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002708394,"about_ca_system_score_gemma":0.00007224201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000360073,"about_ca_topic_score_gemma":8.587663e-7,"domain_scores_codex":[0.9981495,0.0001094857,0.0002919704,0.0008276065,0.0001380887,0.0004833055],"domain_scores_gemma":[0.9989675,0.00003115987,0.0001702386,0.0006432481,0.0001188248,0.00006908751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001533763,0.000007144599,0.00002813635,0.00001784035,0.00003926774,0.000005293542,7.978005e-7,1.397855e-8,0.3883612,0.00003263793,0.6106885,0.0008037571],"study_design_scores_gemma":[0.0002389455,0.00007425323,0.000001275482,0.000009885345,0.0000149901,0.00002433299,5.113021e-7,0.000001100305,0.3650641,0.0002364617,0.6340638,0.0002703143],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01703578,0.008741052,0.0007549207,0.9486087,0.003812817,0.000730355,0.0002587954,0.0001697235,0.01988787],"genre_scores_gemma":[0.05041393,0.0001177282,0.000775946,0.9132715,0.01761247,0.00005472833,0.01254906,0.00007898899,0.005125606],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03533715,"threshold_uncertainty_score":0.9999012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140919982303847,"score_gpt":0.2657429728742807,"score_spread":0.2543337730512423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}