{"id":"W1993540519","doi":"10.1001/jama.285.4.444","title":"Safety Outcomes in Meta-analyses of Phase 2 vs Phase 3 Randomized Trials","year":2001,"lang":"en","type":"review","venue":"JAMA","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton General Hospital","funders":"","keywords":"Medicine; Randomized controlled trial; Myocardial infarction; Meta-analysis; Odds ratio; Adverse effect; Thrombolysis; Confidence interval; Internal medicine; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","metaepi_broad","insufficient_payload"],"consensus_categories":["metaepi_broad"],"category_scores_codex":[0.01006575,0.000810286,0.03363239,0.0009642434,0.00001984077,0.00002372621,0.0003840407,0.0004168793,0.003964888],"category_scores_gemma":[0.01736881,0.0004273952,0.009948021,0.0007715535,0.0001400958,0.00007478981,0.0001571487,0.000555164,0.00007105505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002076586,"about_ca_system_score_gemma":0.0002354393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000110686,"about_ca_topic_score_gemma":0.000002291526,"domain_scores_codex":[0.9904952,0.002392821,0.005355998,0.0006217804,0.0007547463,0.0003794666],"domain_scores_gemma":[0.9889229,0.006645535,0.002954906,0.001179207,0.0001396605,0.0001578101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03226805,0.00136172,7.890753e-7,0.008065529,0.07577684,0.0002853511,0.00002822197,3.365785e-7,0.000005423575,0.00003004974,0.02593779,0.8562399],"study_design_scores_gemma":[0.2735032,0.00008534977,9.558608e-8,0.001336445,0.1873485,0.00001593071,0.000009025296,0.000006247577,0.00002238508,0.000004285224,0.5375066,0.0001619617],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001371104,0.9782459,0.0007610316,0.0007531471,0.0002037245,0.006072037,0.0003709144,0.0000431435,0.01353644],"genre_scores_gemma":[0.00001693785,0.9862053,0.001502184,0.0003773917,0.0003003649,0.0006862239,0.0006250368,0.00007207876,0.01021451],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8560779,"threshold_uncertainty_score":0.9999671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3256103953539055,"score_gpt":0.5127544323252616,"score_spread":0.1871440369713561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}