{"id":"W1993564924","doi":"10.1002/path.1553","title":"Cleavage of AL amyloid proteins and AL amyloid deposits by cathepsins B, K, and L","year":2004,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"Deutsche Forschungsgemeinschaft","keywords":"Proteases; Cathepsin B; Cathepsin; Amyloid (mycology); Proteolysis; Chemistry; Extracellular; P3 peptide; Biochemistry; Amyloid precursor protein; Molecular biology; Biology; Pathology; Alzheimer's disease; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003218855,0.0002455619,0.0002630747,0.0001888381,0.0001791164,0.0003297837,0.00008352805,0.0003478908,0.0008396591],"category_scores_gemma":[0.0005707317,0.0001244909,0.0002558615,0.0001164208,0.0003344951,0.0002591456,0.0002421336,0.0002560841,0.0001750719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000288432,"about_ca_system_score_gemma":0.0002044209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000436884,"about_ca_topic_score_gemma":0.0003302355,"domain_scores_codex":[0.9997624,0.00007000456,0.00002130452,0.00004305529,0.00005080081,0.00005250775],"domain_scores_gemma":[0.9997869,0.0000521853,0.00006814443,0.00001995281,0.00003213995,0.00004061584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004928322,0.00006930122,0.003769902,0.0001096287,0.00002235737,0.0005422628,0.00006995248,0.000058013,0.9878497,0.0001416488,0.00004551834,0.006828927],"study_design_scores_gemma":[0.00006765281,0.001503906,0.03952684,0.0000192198,0.00004707719,0.007040155,0.0001504384,0.000944972,0.9478708,0.0002379919,0.002580903,0.00001001433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941807,0.00340914,0.001397215,0.00005230122,0.000006990289,0.00001612201,0.000030492,0.00001671871,0.0008901631],"genre_scores_gemma":[0.9971135,0.0007165289,0.001123615,0.00003143034,0.000005688485,0.0000109986,0.0000737215,0.000004415088,0.0009201514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008396591,"threshold_uncertainty_score":0.002808928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007715704543328604,"score_gpt":0.2513720381191725,"score_spread":0.2436563335758439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}