{"id":"W1993584752","doi":"10.1007/s10549-011-1816-4","title":"IGFBP7 reduces breast tumor growth by induction of senescence and apoptosis pathways","year":2011,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Senescence; Breast cancer; Apoptosis; Cancer research; Breast tumor; Signal transduction; Cellular senescence; Mammary gland; Medicine; Internal medicine; Oncology; Biology; Cancer; Cell biology; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490431,0.0004001544,0.0003244464,0.0004002893,0.0002939375,0.0004204978,0.0002875899,0.000385932,0.004971582],"category_scores_gemma":[0.0002424965,0.0001892894,0.0004357888,0.0001666469,0.0002265408,0.0001536708,0.0001730258,0.0008745743,0.0008975361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006761005,"about_ca_system_score_gemma":0.0009026204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005109394,"about_ca_topic_score_gemma":0.01072963,"domain_scores_codex":[0.9998295,0.00003273617,0.00001130597,0.00001005666,0.00005614801,0.00006020184],"domain_scores_gemma":[0.9998778,0.00001993289,0.00001946389,0.00001383713,0.00002606569,0.00004281281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009394185,0.0009288038,0.001511621,0.0003006394,0.0001489131,0.0001632364,0.00004913742,0.0003743304,0.935179,0.000384481,0.004078755,0.04748688],"study_design_scores_gemma":[0.001216652,0.009609288,0.04122991,0.00006139349,0.0003258738,0.0008414514,0.0002228923,0.001864418,0.9117591,0.0003688883,0.03244919,0.00005088485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637135,0.02073735,0.001478723,0.001888531,0.0004966895,0.00006357909,0.001177618,0.0006278869,0.009816105],"genre_scores_gemma":[0.9774851,0.006689492,0.001263366,0.0004949117,0.0001127291,0.00004870314,0.001477334,0.00004104921,0.01238739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005109394,"threshold_uncertainty_score":0.01663166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08185198898811565,"score_gpt":0.3178326369158198,"score_spread":0.2359806479277042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}