{"id":"W1993600822","doi":"10.1073/pnas.1001520107","title":"Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":445,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Università degli Studi di Padova; Canada Research Chairs; Michael Smith Health Research BC; Hastings Foundation; University of Washington","keywords":"Bleomycin; Wnt signaling pathway; Pulmonary fibrosis; Idiopathic pulmonary fibrosis; Cancer research; Medicine; Fibrosis; Beta-catenin; Catenin; Lung; Signal transduction; Pathology; Internal medicine; Biology; Cell biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007767516,0.0003664056,0.0002584767,0.0003376136,0.000114671,0.0001731349,0.0002014111,0.0002102234,0.001310279],"category_scores_gemma":[0.00006119053,0.00006588959,0.0001332753,0.0001267877,0.0002692491,0.0001087199,0.0000936178,0.000773298,0.0002710099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002519219,"about_ca_system_score_gemma":0.0003042461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000848086,"about_ca_topic_score_gemma":0.002431851,"domain_scores_codex":[0.9999582,0.000006029109,0.000002595732,0.000005516257,0.00001289901,0.00001476286],"domain_scores_gemma":[0.9999704,0.000004359073,0.000006269938,0.00000222226,0.00000316349,0.00001341312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006912943,0.0005292518,0.0003061141,0.0002096519,0.00001733982,0.000135268,0.00001783525,0.0001997214,0.964402,0.0003601253,0.0005335213,0.0325979],"study_design_scores_gemma":[0.0003739453,0.003619515,0.01048972,0.00003329767,0.00004954294,0.0006200392,0.00005164071,0.001078432,0.9706369,0.0001625089,0.01287535,0.00000907021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757106,0.01384438,0.002463905,0.0005577388,0.0001669448,0.00008617334,0.0002765379,0.0003087585,0.006584868],"genre_scores_gemma":[0.9827579,0.008580459,0.001955469,0.0001572109,0.00003362826,0.00005220233,0.0003866378,0.00001815971,0.006058393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310279,"threshold_uncertainty_score":0.004383326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02625535506683897,"score_gpt":0.2845918638764665,"score_spread":0.2583365088096275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}