{"id":"W1993602050","doi":"10.1038/sj.emboj.7601380","title":"Cap‐free structure of eIF4E suggests a basis for conformational regulation by its ligands","year":2006,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; U.S. Public Health Service; Chugai Pharmaceutical; National Institutes of Health","keywords":"EIF4E; EIF4G; Biology; Biophysics; Binding site; Protein structure; Conformational change; Plasma protein binding; Biochemistry; Translation (biology); Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002221624,0.0004320036,0.0003020165,0.0001388102,0.0005955319,0.0005454328,0.0004875886,0.0004770638,0.00386416],"category_scores_gemma":[0.0003437351,0.0002451543,0.0004047702,0.000150016,0.0004870707,0.0007543367,0.0002957379,0.0008987332,0.0009044575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005219153,"about_ca_system_score_gemma":0.0002557183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002877619,"about_ca_topic_score_gemma":0.0002688291,"domain_scores_codex":[0.9999336,0.000009981017,0.00000430543,0.00001955982,0.000009753453,0.00002278533],"domain_scores_gemma":[0.9998715,0.00002892094,0.00002253815,0.00002193796,0.00001626843,0.00003889222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001171122,0.00009854678,0.001215702,0.0002209098,0.0000651701,0.001179992,0.0001591568,0.005699967,0.9560186,0.02273554,0.001690077,0.009745298],"study_design_scores_gemma":[0.0001496829,0.0004860385,0.005677562,0.00002785945,0.00004386943,0.0008125312,0.0001811193,0.01466914,0.9495048,0.009971333,0.01840049,0.00007554144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9568126,0.002938864,0.02646703,0.001916526,0.0004347789,0.00004493025,0.0004980391,0.0003189734,0.01056817],"genre_scores_gemma":[0.9928811,0.0004561726,0.003393563,0.0002463373,0.00004619086,0.00002182172,0.0004827076,0.00003021354,0.002441842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00386416,"threshold_uncertainty_score":0.01292694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006036209893999007,"score_gpt":0.2361393206924178,"score_spread":0.2301031107984188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}