{"id":"W1993609519","doi":"10.1016/j.ejpn.2015.02.008","title":"Efficacy and safety of perampanel in adolescent patients with drug-resistant partial seizures in three double-blind, placebo-controlled, phase III randomized clinical studies and a combined extension study","year":2015,"lang":"en","type":"article","venue":"European Journal of Paediatric Neurology","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCB Pharma; H. Lundbeck A/S; Upsher-Smith; Sunovion; Pfizer; Viropharma; GlaxoSmithKline; Eisai; Valeant Pharmaceuticals International","keywords":"Perampanel; Somnolence; Placebo; Medicine; Anesthesia; Adverse effect; Adjunctive treatment; MedDRA; Epilepsy; Post-hoc analysis; Psychology; Internal medicine; Psychiatry; Pharmacovigilance","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005916342,0.00141577,0.004715875,0.0006288433,0.0004417361,0.0008986043,0.0009550129,0.001222988,0.001784755],"category_scores_gemma":[0.00349955,0.0008674217,0.002229369,0.0006199471,0.0009044248,0.0009136852,0.0005180839,0.002019465,0.0003317223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008283948,"about_ca_system_score_gemma":0.002054494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000553674,"about_ca_topic_score_gemma":0.002039966,"domain_scores_codex":[0.9966948,0.002235048,0.0003411673,0.0002571199,0.0002655131,0.0002063123],"domain_scores_gemma":[0.9960794,0.00109326,0.00101798,0.0004131422,0.0004335784,0.000962774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.909575,0.01983384,0.005964546,0.001175871,0.002431898,0.0001004167,0.0002262461,0.0004016405,0.01210007,0.0000964825,0.0004114014,0.04768265],"study_design_scores_gemma":[0.7025142,0.2803138,0.0131246,0.00008052828,0.001126486,0.0001565576,0.00005011027,0.0003898037,0.001457322,0.00007783734,0.0006813352,0.0000274102],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914361,0.003392303,0.0006899695,0.0001121705,0.00005501095,0.003364059,0.0003478623,0.00004355689,0.0005590413],"genre_scores_gemma":[0.988269,0.00238853,0.002563501,0.0002735618,0.000135784,0.005387671,0.0006425663,0.00001089821,0.0003284689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005916342,"threshold_uncertainty_score":0.03128898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0678808821006577,"score_gpt":0.360664491566171,"score_spread":0.2927836094655134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}