{"id":"W1993612411","doi":"10.1038/gt.2011.91","title":"Efficient cochlear gene transfection in guinea-pigs with adeno-associated viral vectors by partial digestion of round window membrane","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"National Eye Institute","keywords":"Round window; Transfection; Cochlea; Biology; Genetic enhancement; Adeno-associated virus; Collagenase; Viral vector; Gene delivery; Inner ear; Cell biology; Vector (molecular biology); Molecular biology; Gene; Recombinant DNA; Anatomy; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004071029,0.0002802929,0.0003421605,0.0001691766,0.0001195081,0.00002998194,0.0002678154,0.0001711446,0.0001440143],"category_scores_gemma":[0.00008584696,0.000258297,0.00007694116,0.0006149113,0.0001789382,0.00007148046,0.00002179262,0.0002493622,0.00002586552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001257022,"about_ca_system_score_gemma":0.0001004669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006818936,"about_ca_topic_score_gemma":0.00009751673,"domain_scores_codex":[0.9975826,0.0003593638,0.0004561628,0.0005463826,0.0005253893,0.0005301563],"domain_scores_gemma":[0.9991846,0.00007243887,0.0001827935,0.0003668796,0.00007550504,0.0001177595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008646217,0.0006316671,0.003812661,0.000008177751,0.00002189974,0.00001184559,0.002524729,0.00345757,0.987111,0.00001705446,0.00001309665,0.001525699],"study_design_scores_gemma":[0.002652549,0.001379851,0.03274799,0.00002685321,0.0000179429,0.0000128319,0.00002834261,0.001417537,0.9612462,0.00001774871,0.0001760019,0.0002761331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977412,0.0002363769,0.0007918754,0.00004932786,0.0002476213,0.0006195531,0.00003340067,0.0001076035,0.0001730253],"genre_scores_gemma":[0.9990413,0.000386356,0.0001650862,0.0001390832,0.00006386964,0.00003173824,0.00001480975,0.00006339263,0.00009442463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02893533,"threshold_uncertainty_score":0.9999869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03537903974621633,"score_gpt":0.2426613134535286,"score_spread":0.2072822737073123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}