{"id":"W1993619070","doi":"10.1371/journal.pone.0084958","title":"Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Plant Reproductive Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"National Cancer Institute; Kansas Bioscience Authority","keywords":"Furin; Proprotein Convertases; Proprotein convertase; Kexin; Proteases; Biology; Biochemistry; Enzyme; Cell biology; LDL receptor; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348884,0.0003242092,0.0003801254,0.0002644705,0.0003335947,0.0005584321,0.0001274184,0.00031927,0.001067935],"category_scores_gemma":[0.0001413449,0.0001953814,0.0003489863,0.0001782752,0.0002085239,0.0003746392,0.0002056336,0.0004565178,0.0007029336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005616628,"about_ca_system_score_gemma":0.0003443872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000679062,"about_ca_topic_score_gemma":0.0005841355,"domain_scores_codex":[0.999848,0.00001234948,0.00001413252,0.00004908446,0.00003665278,0.00003965031],"domain_scores_gemma":[0.9998568,0.00001975093,0.00005540321,0.00001077811,0.00001930522,0.00003790672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008644775,0.000005701619,0.0005176231,0.00004089029,0.000005818988,0.0001802118,0.00001751586,0.00006944781,0.9972573,0.0001678146,0.0000385695,0.001612729],"study_design_scores_gemma":[0.00001017061,0.0000727741,0.01754148,0.000009346621,0.00001556081,0.001141206,0.00006223298,0.0008970699,0.9744607,0.000182938,0.005597154,0.000009254324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803281,0.005300356,0.01036455,0.0001878674,0.00004540889,0.00004540863,0.001421112,0.000186499,0.002120564],"genre_scores_gemma":[0.9876279,0.001371058,0.005650608,0.0000450309,0.00001239145,0.00001528878,0.001820629,0.00003354483,0.003423611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001067935,"threshold_uncertainty_score":0.004075229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03042711627079796,"score_gpt":0.2418164452094157,"score_spread":0.2113893289386177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}