{"id":"W1993655397","doi":"10.1002/iub.135","title":"Beyond AICA riboside: In search of new specific AMP‐activated protein kinase activators","year":2008,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"National Institute on Minority Health and Health Disparities; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Pfizer; National Heart, Lung, and Blood Institute; Fonds De La Recherche Scientifique - FNRS; National Institute on Aging; Diabetes UK; GlaxoSmithKline; Medical Research Council; Merck KGaA; AstraZeneca; European Commission","keywords":"AMPK; Protein kinase A; AMP-activated protein kinase; Phosphorylation; Oxidative phosphorylation; Mitochondrion; Cell biology; Chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003286375,0.0008918709,0.0009305097,0.00133489,0.0002365947,0.0007068696,0.0007485592,0.0009892705,0.002335876],"category_scores_gemma":[0.0002522757,0.0002562883,0.0003152439,0.001711061,0.0004065161,0.00138601,0.0004735459,0.001531136,0.003212741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005197699,"about_ca_system_score_gemma":0.0004360213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004777557,"about_ca_topic_score_gemma":0.0008168653,"domain_scores_codex":[0.999887,0.00002230015,0.00001426703,0.0000294951,0.00003493976,0.00001193383],"domain_scores_gemma":[0.9998807,0.00004692347,0.00002134602,0.000007146678,0.00002663343,0.00001731606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002236602,0.0001427993,0.0002223508,0.009279353,0.00008212532,0.0008847688,0.00009594192,0.0007954475,0.03278492,0.005081059,0.01476878,0.9356388],"study_design_scores_gemma":[0.00005941037,0.0003389335,0.000747312,0.0006669564,0.0001059838,0.002600996,0.00005403941,0.0002340813,0.009339324,0.002063747,0.9837637,0.0000255994],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006469159,0.996545,0.0006476597,0.0002256556,0.0001898781,0.000008489385,0.00001631482,0.00002112539,0.001698993],"genre_scores_gemma":[0.003100547,0.9931078,0.001022288,0.0004467041,0.0002467267,0.0000173735,0.0000627429,0.000005515084,0.001990172],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002335876,"threshold_uncertainty_score":0.007814288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0517538851078739,"score_gpt":0.323462175047413,"score_spread":0.2717082899395391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}