{"id":"W1993700011","doi":"10.1371/journal.pone.0088168","title":"Activation of Transcription Factor Nrf2 Signalling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Daiichi-Sankyo; National Institute for Health and Care Research; Wellcome Trust","keywords":"KEAP1; Oxidative stress; Sphingosine kinase; Transcription factor; Inflammation; Cell biology; Kinase; Activator (genetics); Sphingosine; Chemistry; Oxidative phosphorylation; Cancer research; Biology; Immunology; Biochemistry; Sphingosine-1-phosphate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308096,0.0004409435,0.0002507044,0.00015467,0.0001195887,0.0002012366,0.0001597562,0.0001961866,0.002956864],"category_scores_gemma":[0.00008840572,0.0001056834,0.0003169034,0.0001256356,0.0001974147,0.0002412864,0.0001943452,0.0005329004,0.0006962221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222639,"about_ca_system_score_gemma":0.0002143406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002003656,"about_ca_topic_score_gemma":0.0003736325,"domain_scores_codex":[0.9999162,0.00001009768,0.000008835506,0.00002018358,0.00002206459,0.00002263575],"domain_scores_gemma":[0.9999194,0.000007440806,0.00003653998,0.000005984515,0.0000112423,0.00001935262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001964052,0.0000206972,0.0001061977,0.00007879004,0.000005889815,0.0000193801,0.000005203304,0.00003329318,0.9987906,0.00003446438,0.00004166811,0.0006673819],"study_design_scores_gemma":[0.00003183134,0.000301009,0.001558447,0.000008558085,0.00001644159,0.0001451665,0.00001186411,0.0003703273,0.9956192,0.00003278329,0.001900802,0.000003475241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773586,0.008770062,0.008624693,0.0003827323,0.0001340495,0.0001023049,0.001328294,0.0002250171,0.003074255],"genre_scores_gemma":[0.9915046,0.002462809,0.002443042,0.0000711696,0.00002963394,0.00005690669,0.001069889,0.00001647016,0.002345474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002956864,"threshold_uncertainty_score":0.009891689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871452283306702,"score_gpt":0.2065799902934875,"score_spread":0.1878654674604205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}