{"id":"W1993700109","doi":"10.1038/gt.2015.13","title":"Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus","year":2015,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Barts Cancer Institute; Medical Research Council; Science and Technology Department of Henan Province; Deutsche Forschungsgemeinschaft; Royal College of Surgeons of England; Cancer Research UK","keywords":"Oncolytic virus; Vaccinia; Biology; Thymidine kinase; Virus; Virology; In vivo; Gene; Genetics; Recombinant DNA; Herpes simplex virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005759672,0.0002499133,0.0003087859,0.0001055152,0.00006827525,0.00002110774,0.000247351,0.0001687573,0.00006836194],"category_scores_gemma":[0.00001651103,0.0002115361,0.00009617158,0.0001695039,0.00004195145,0.00001502449,0.00003518712,0.00007127498,0.000004864459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007353895,"about_ca_system_score_gemma":0.001188205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000744235,"about_ca_topic_score_gemma":0.0006774515,"domain_scores_codex":[0.9984012,0.00004689628,0.0004617452,0.00038994,0.0003555574,0.0003446161],"domain_scores_gemma":[0.9987697,0.0000114396,0.0002328663,0.000457586,0.0003440592,0.0001843331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01148737,0.000240192,0.00003629167,0.0000183262,0.0002025688,0.000001057273,0.0009265551,0.0003156526,0.9358755,0.000003166278,0.0009974558,0.04989583],"study_design_scores_gemma":[0.004768974,0.007820592,0.0001234017,0.00001186619,0.00001759947,0.000007328487,0.00005365683,0.0003546868,0.9756159,0.00004935556,0.01093128,0.0002453796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863769,0.002256285,0.01017451,0.0001057124,0.00005471883,0.0008522195,0.0001323753,0.0000106896,0.00003652208],"genre_scores_gemma":[0.9775335,0.000639597,0.01967181,0.0003887011,0.000398384,0.0001390109,0.0005979984,0.00007536889,0.0005557006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04965045,"threshold_uncertainty_score":0.862619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1005531374183419,"score_gpt":0.3342027383471454,"score_spread":0.2336496009288035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}