{"id":"W1993700109","doi":"10.1038/gt.2015.13","title":"Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus","year":2015,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Barts Cancer Institute; Medical Research Council; Science and Technology Department of Henan Province; Deutsche Forschungsgemeinschaft; Royal College of Surgeons of England; Cancer Research UK","keywords":"Oncolytic virus; Vaccinia; Biology; Thymidine kinase; Virus; Virology; In vivo; Gene; Genetics; Recombinant DNA; Herpes simplex virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002638054,0.0004974033,0.0003661933,0.0004977529,0.0002035739,0.0004240923,0.0004086206,0.0003504902,0.00067943],"category_scores_gemma":[0.000151953,0.0003031239,0.0003334956,0.0002026909,0.0003756432,0.0003799641,0.0004089089,0.001089359,0.0006808488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003740304,"about_ca_system_score_gemma":0.0003678218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002961507,"about_ca_topic_score_gemma":0.0004102718,"domain_scores_codex":[0.9998368,0.00002758746,0.00001316023,0.0000350218,0.00005420539,0.00003325837],"domain_scores_gemma":[0.9998506,0.00002951457,0.00005990535,0.00002209171,0.000008531804,0.00002923226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007578189,0.00002226146,0.000143681,0.00002352934,0.000004041726,0.0000510992,0.00001470031,0.00006987463,0.9970068,0.001092777,0.00006355838,0.001431922],"study_design_scores_gemma":[0.00001943316,0.0001695004,0.0005562408,0.000006442084,0.00001398604,0.0003102892,0.00001073751,0.0006527292,0.9916241,0.0001961188,0.00643175,0.000008806141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8721727,0.002999512,0.1164288,0.0003143683,0.0001668653,0.0001630278,0.001449007,0.001283199,0.005022382],"genre_scores_gemma":[0.9339524,0.001649739,0.05536081,0.00006308923,0.00003626211,0.0001119066,0.002403472,0.0002213531,0.006201006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00067943,"threshold_uncertainty_score":0.002713799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1005531374183419,"score_gpt":0.3342027383471454,"score_spread":0.2336496009288035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}