{"id":"W1993712330","doi":"10.1021/jo010164d","title":"Solid-Phase Synthesis of Peptidomimetic Inhibitors for the Hepatitis C Virus NS3 Protease","year":2001,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Peptidomimetic; NS3; Chemistry; Protease; Serine protease; NS2-3 protease; Hepatitis C virus; Enzyme; Cleavage (geology); Solid-phase synthesis; Biochemistry; Stereochemistry; Combinatorial chemistry; Virology; Virus; Peptide; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006204119,0.0001570784,0.0002889516,0.00001493467,0.0001104432,0.00001664839,0.0004930877,0.0001110304,0.0003786678],"category_scores_gemma":[0.001053829,0.00008908202,0.0003636911,0.0001417544,0.0001544448,0.000004527872,0.00008176776,0.0001418192,0.000001781323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002516309,"about_ca_system_score_gemma":0.0001031406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002507071,"about_ca_topic_score_gemma":0.000009948834,"domain_scores_codex":[0.9989029,0.00004423022,0.0005213141,0.0001253334,0.0002169171,0.0001893],"domain_scores_gemma":[0.9985346,0.000258572,0.0005335971,0.0003790793,0.0002047067,0.0000894914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003190661,0.0001730334,0.0002508986,0.00003809781,0.0002850701,0.00000262652,0.00002870234,0.00001393369,0.9944976,3.250701e-7,0.001460571,0.002930049],"study_design_scores_gemma":[0.0005797262,0.00008809941,0.00005009292,0.00005035228,0.000481896,0.0001393316,0.0001275941,0.00006499463,0.9938586,0.00003844491,0.004409697,0.0001111917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956447,0.001338713,0.001951548,0.0007750713,0.00003933024,0.0001273514,0.00002439269,0.00000283549,0.00009609178],"genre_scores_gemma":[0.996658,0.002205345,0.000133483,0.00006359467,0.0006172613,0.000009548926,0.000004028789,0.00002437691,0.0002843073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002949127,"threshold_uncertainty_score":0.4146147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007650412093524858,"score_gpt":0.2766769828314036,"score_spread":0.2690265707378787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}