{"id":"W1993712330","doi":"10.1021/jo010164d","title":"Solid-Phase Synthesis of Peptidomimetic Inhibitors for the Hepatitis C Virus NS3 Protease","year":2001,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Peptidomimetic; NS3; Chemistry; Protease; Serine protease; NS2-3 protease; Hepatitis C virus; Enzyme; Cleavage (geology); Solid-phase synthesis; Biochemistry; Stereochemistry; Combinatorial chemistry; Virology; Virus; Peptide; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000239335,0.000558924,0.0005529006,0.0003128305,0.0002178446,0.0003349782,0.0003588446,0.0003674772,0.002728926],"category_scores_gemma":[0.0003318992,0.0002947359,0.0003162955,0.0004232897,0.0001780975,0.0003202821,0.0002163482,0.0006532818,0.001365248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003467098,"about_ca_system_score_gemma":0.0005630685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002527806,"about_ca_topic_score_gemma":0.0007076538,"domain_scores_codex":[0.9997999,0.00002846843,0.00001610964,0.0000214825,0.0001022524,0.00003179802],"domain_scores_gemma":[0.9998746,0.00003657289,0.00002997776,0.000008281012,0.00001742264,0.00003310078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003007205,0.000198843,0.00005384531,0.0003746416,0.00002453669,0.0001925122,0.00003455647,0.003602742,0.9763303,0.001846465,0.0006453699,0.01639527],"study_design_scores_gemma":[0.0003224337,0.001567014,0.0002382204,0.00002267956,0.00003037374,0.0002318587,0.0000148966,0.00609114,0.9715892,0.0005196754,0.01934719,0.00002532729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.753014,0.02728137,0.1715931,0.0007806198,0.001195996,0.002167488,0.004795023,0.001657794,0.03751455],"genre_scores_gemma":[0.8610265,0.01765582,0.102724,0.0002414573,0.0001482415,0.0007907852,0.003503405,0.0001739026,0.01373602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002728926,"threshold_uncertainty_score":0.009129226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007650412093524858,"score_gpt":0.2766769828314036,"score_spread":0.2690265707378787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}