{"id":"W1993749475","doi":"10.3892/ijo.16.5.971","title":"Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs.","year":2000,"lang":"en","type":"article","venue":"International Journal of Oncology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health","keywords":"Caffeine; Cell cycle; Cell cycle checkpoint; DNA damage; G2-M DNA damage checkpoint; Biology; Biological activity; Structure–activity relationship; Apoptosis; DNA; Oncogene; Pharmacology; Toxicity; Cancer research; Toxicology; Chemistry; Biochemistry; In vitro; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003299159,0.0001106157,0.00028557,0.0001957347,0.00004731568,0.00001441231,0.0001043253,0.0001943793,0.000883089],"category_scores_gemma":[0.0002897208,0.0001005199,0.0001867885,0.00009279721,0.00006715457,0.0001394105,0.00001356981,0.0004964987,0.00001237735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008073044,"about_ca_system_score_gemma":0.0003666642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002587941,"about_ca_topic_score_gemma":0.00004801609,"domain_scores_codex":[0.998827,0.00008294479,0.0004633145,0.0001381235,0.0003465911,0.000141963],"domain_scores_gemma":[0.998706,0.0001312421,0.0003737325,0.00009195257,0.0005770806,0.0001199371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006830318,0.0009729541,0.001493696,0.00002736563,0.001091428,0.0005977406,0.0004518998,0.001112895,0.6974335,0.0006980763,0.04680328,0.2424869],"study_design_scores_gemma":[0.02134348,0.006368023,0.02787901,0.0002912718,0.000531799,0.01178531,0.00009513745,0.001809733,0.2312054,0.005539041,0.6927587,0.0003931616],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778442,0.0002723305,0.007584316,0.01018244,0.0009732258,0.0002348029,0.0001187935,0.00001553626,0.002774374],"genre_scores_gemma":[0.9955271,0.000118783,0.002623286,0.0005469313,0.0006607709,0.000006425783,0.00008856656,0.00001829336,0.0004098032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6459554,"threshold_uncertainty_score":0.9669205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02624682238925284,"score_gpt":0.3299327795816743,"score_spread":0.3036859571924215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}