{"id":"W1993778243","doi":"10.1074/jbc.m109.018275","title":"Polo-like Kinase 1 (PLK1) Regulates Interferon (IFN) Induction by MAVS","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"PLK1; Cell biology; Nocodazole; Biology; Polo-like kinase; Phosphorylation; IRF3; Kinase; Transcription factor; Biochemistry; Cell cycle; Gene; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003026522,0.0002069287,0.0003870227,0.00004553516,0.00008605953,0.00002045634,0.0003330845,0.0005502155,0.001523598],"category_scores_gemma":[0.000174442,0.0001381292,0.0002197073,0.00006857431,0.0002207448,0.00009221423,0.00004774147,0.0007001408,0.00007749349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007973475,"about_ca_system_score_gemma":0.00003705059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003416409,"about_ca_topic_score_gemma":8.429991e-8,"domain_scores_codex":[0.9987561,0.0001414779,0.0005584307,0.0001899724,0.00004339965,0.000310586],"domain_scores_gemma":[0.9992209,0.00008622206,0.0003652565,0.000172826,0.000107388,0.00004739851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001831859,0.0002307477,0.00008783682,0.000005727999,0.00007197692,0.00001585635,0.00004071721,4.414125e-7,0.9622341,0.000009675516,0.02815079,0.007320226],"study_design_scores_gemma":[0.0007779576,0.001634383,0.001943939,0.00005879447,0.0000206181,0.001051302,0.0002395271,3.940844e-7,0.941299,0.0001729257,0.05263997,0.0001611461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907325,0.006500278,0.00004714582,0.001080583,0.0004947389,0.00004396159,0.00001131655,0.00003163117,0.001057842],"genre_scores_gemma":[0.9949742,0.0003357224,0.00004283104,0.0004003748,0.0001161284,9.441254e-7,0.00003806156,0.000006434297,0.004085296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02448918,"threshold_uncertainty_score":0.9993892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518736968323459,"score_gpt":0.2449826648555539,"score_spread":0.2297952951723193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}