{"id":"W1993791286","doi":"10.1038/nature01870","title":"A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme","year":2003,"lang":"en","type":"article","venue":"Nature","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":241,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Fonds De La Recherche Scientifique - FNRS; Canadian Institutes of Health Research; Uehara Memorial Foundation; Japan Science and Technology Corporation; Hospital for Sick Children; Japan Health Sciences Foundation; Wellcome Trust; Wenner-Gren Foundation","keywords":"Lysozyme; Point mutation; Protein aggregation; Cooperativity; Chemistry; Epitope; Amyloid (mycology); Mutant; Antibody; Protein structure; Mutation; Protein engineering; Amyloidosis; Fibril; Biochemistry; Molecular biology; Biophysics; Cell biology; Gene; Biology; Genetics; Enzyme; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003294299,0.0003862648,0.000421983,0.0002909437,0.0001667668,0.0003050277,0.0003905718,0.0005721388,0.0009974887],"category_scores_gemma":[0.0002611064,0.0002182352,0.0004799674,0.0001070324,0.0002467899,0.0002070006,0.0001849906,0.0007462274,0.0004215219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004395835,"about_ca_system_score_gemma":0.000153544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000422582,"about_ca_topic_score_gemma":0.0004477015,"domain_scores_codex":[0.9998116,0.00002825088,0.00001886306,0.00002891816,0.00005062933,0.00006182565],"domain_scores_gemma":[0.9997823,0.00006911762,0.00004166595,0.00002915623,0.00002843792,0.00004926991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002201373,0.0000577841,0.0001666079,0.00002493981,0.000009197543,0.00008395782,0.000009079533,0.0000346754,0.9985989,0.00004123048,0.00005301131,0.0007005248],"study_design_scores_gemma":[0.00008356116,0.0006466371,0.003503007,0.000005737323,0.00002688164,0.0005912241,0.000007128695,0.0004614553,0.9934251,0.00002093826,0.001224425,0.000003882581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954991,0.001703867,0.001467462,0.0001036448,0.00003873333,0.0000215475,0.0001104726,0.00005007215,0.001005005],"genre_scores_gemma":[0.9960868,0.0006968892,0.0009840172,0.0001096405,0.00003713924,0.00001559293,0.0005718902,0.00002274239,0.001475213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009974887,"threshold_uncertainty_score":0.003336906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01299074486966742,"score_gpt":0.3305933815908723,"score_spread":0.3176026367212049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}