{"id":"W1993795170","doi":"10.1016/j.jalz.2010.05.1398","title":"P2‐347: Absence of MDR‐1 P‐glycoprotein at the blood‐brain barrier increased the passage of blood‐borne exogenous Aβ peptides across the BBB into the brain","year":2010,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Ottawa; Institute for Biological Sciences","funders":"","keywords":"Blood–brain barrier; Transporter; P-glycoprotein; In vivo; Glycoprotein; Pathogenesis; Receptor; Biology; Ex vivo; Knockout mouse; Pharmacology; In vitro; Cell biology; Molecular biology; Chemistry; Immunology; Central nervous system; Biochemistry; Gene; Neuroscience; Multiple drug resistance; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002254916,0.0006383595,0.001015734,0.0004037821,0.0002585879,0.0005591963,0.0004113502,0.001015485,0.005855365],"category_scores_gemma":[0.0002057685,0.0003620362,0.0005453122,0.000311464,0.0007379132,0.0007920914,0.0002769967,0.002504878,0.001304771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003220436,"about_ca_system_score_gemma":0.0003329593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008692788,"about_ca_topic_score_gemma":0.0005437311,"domain_scores_codex":[0.9996061,0.00004918428,0.00003449314,0.00008523151,0.00008367215,0.0001414447],"domain_scores_gemma":[0.9997507,0.00003091835,0.00004680573,0.00002561843,0.0000312117,0.0001147783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006476476,0.0002609339,0.0001691274,0.00009042092,0.00001768004,0.0002479345,0.00003474811,0.00004469727,0.9967517,0.0002432007,0.0003634686,0.001128379],"study_design_scores_gemma":[0.0001658199,0.002404004,0.003761291,0.00001954415,0.00009007215,0.001098097,0.0001118816,0.001237776,0.9845509,0.0002614657,0.006273743,0.00002541649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915509,0.001490469,0.002387111,0.0008573062,0.0002959112,0.00005816459,0.001056924,0.0002436579,0.002059571],"genre_scores_gemma":[0.9853294,0.001657475,0.001718778,0.0004111751,0.00008363417,0.0001708736,0.001208062,0.0001553897,0.009265108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005855365,"threshold_uncertainty_score":0.01958811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009988894382497749,"score_gpt":0.2504189673797131,"score_spread":0.2404300729972154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}