{"id":"W1993860951","doi":"10.1371/journal.pbio.1001250","title":"The Chromosomal Passenger Complex Activates Polo Kinase at Centromeres","year":2012,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; National Institutes of Health; Cancer Research UK; Wellcome Trust; National Institute of General Medical Sciences; Wellcome","keywords":"Aurora B kinase; Kinetochore; Cell biology; Biology; Centromere; Aurora inhibitor; Spindle checkpoint; Aurora kinase; Chromosome segregation; Polo-like kinase; Spindle apparatus; Genetics; Cell cycle; Cell division; Chromosome; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000914491,0.000167944,0.0001445999,0.00001806248,0.0002523581,0.00001284713,0.0002430194,0.0001998154,0.0001146106],"category_scores_gemma":[0.00005714062,0.0001130836,0.00008771623,0.00004074489,0.0002136081,0.00000317689,0.0002833819,0.00009034396,0.00009133254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002524076,"about_ca_system_score_gemma":0.00002003663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001827164,"about_ca_topic_score_gemma":0.00006384034,"domain_scores_codex":[0.9988659,0.0001219564,0.0001620132,0.0002415593,0.00004723109,0.0005613198],"domain_scores_gemma":[0.9993571,0.00005061065,0.00007877861,0.0003702093,0.00003628523,0.000107038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006326255,0.0001021152,0.02464461,0.000005299701,0.0001094499,5.002263e-7,0.00002343406,4.854131e-7,0.9697294,0.0005971268,0.003796494,0.0009278828],"study_design_scores_gemma":[0.0002494564,0.0001323165,0.007168564,0.000002406214,0.00001977318,0.00001867897,0.00003511972,0.00002016905,0.5485484,0.00003506484,0.4436101,0.0001599381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949496,0.00226057,0.00003838635,0.0006516631,0.0002578106,0.0001601936,0.00005588457,0.00001868118,0.001607201],"genre_scores_gemma":[0.9971672,0.0006420727,0.0001501601,0.0004609267,0.0006677672,0.00003158664,0.0003739695,0.00002186845,0.000484395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4398136,"threshold_uncertainty_score":0.4611416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181324923900999,"score_gpt":0.25310844963229,"score_spread":0.2349759572421901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}