{"id":"W1993861165","doi":"10.1016/j.bpj.2011.11.1791","title":"Direct Evidence of Coupling Between the Selectivity Filter Region and Voltage-Sensor in a Voltage-Dependent Sodium Channel","year":2012,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Gating; Biophysics; Depolarization; Sodium channel; Chemistry; Membrane potential; Conductance; Voltage; Coupling (piping); Selectivity; Tetrodotoxin; CrossBridge; Chemical physics; Materials science; Sodium; Physics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000332571,0.0002183351,0.0002654666,0.0002192724,0.0003644069,0.0004170364,0.0008249037,0.0006976684,0.001445621],"category_scores_gemma":[0.0009727705,0.0003251753,0.0002423232,0.0001819954,0.0006428962,0.0005684285,0.0006699031,0.0007140461,0.000361643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003031286,"about_ca_system_score_gemma":0.0002628859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008222672,"about_ca_topic_score_gemma":0.0007692504,"domain_scores_codex":[0.9997754,0.0000331456,0.00002304185,0.00006729017,0.00006904211,0.00003224691],"domain_scores_gemma":[0.9991361,0.0003898151,0.0001208111,0.0001393198,0.00006219178,0.0001517946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001650389,0.00002420719,0.0008061913,0.0000293248,0.00001211468,0.000139776,0.00003424028,0.00007075149,0.9966169,0.001110319,0.00003522599,0.0009560374],"study_design_scores_gemma":[0.00006356795,0.0002894569,0.01737645,0.000007148899,0.00003809324,0.001345084,0.00004740663,0.004184623,0.9741489,0.001517771,0.0009620864,0.00001942079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846926,0.0003949049,0.01285279,0.0001967281,0.00004636879,0.0000231502,0.0001262114,0.0001182242,0.00154917],"genre_scores_gemma":[0.9967179,0.0001138491,0.00233712,0.000101119,0.00001214059,0.0000116827,0.0001250566,0.00002190432,0.0005593261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445621,"threshold_uncertainty_score":0.004836082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03407671873498801,"score_gpt":0.2717116955663312,"score_spread":0.2376349768313432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}