{"id":"W1993896612","doi":"10.1016/j.tetlet.2009.04.137","title":"Facile and efficient access to 2,6,9-tri-substituted purines through sequential N9, N2 Mitsunobu reactions","year":2009,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Regioselectivity; Combinatorial chemistry; Purine metabolism; Chemoselectivity; Mitsunobu reaction; Nucleophile; Electrophile; Allylic rearrangement; Organic chemistry; Catalysis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008896521,0.0001975182,0.0001460939,0.0000666248,0.0001276275,0.0001005091,0.0002968574,0.0001312376,0.00002866176],"category_scores_gemma":[0.00007160891,0.0001848544,0.00008857313,0.0002069243,0.0001131979,0.000009940813,0.0001603487,0.0001616563,0.00002600201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002794188,"about_ca_system_score_gemma":0.00003068357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007106763,"about_ca_topic_score_gemma":0.000009000722,"domain_scores_codex":[0.9986091,0.00003979304,0.0001947208,0.0005163583,0.0002272767,0.0004128012],"domain_scores_gemma":[0.9993786,0.000008224164,0.00003708056,0.0003436526,0.00005192897,0.0001805484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007365557,0.00007664473,0.0001020789,0.00001501488,0.00002824637,0.00001996461,0.00002465498,0.0002199106,0.986944,0.0000578394,0.01033106,0.002106986],"study_design_scores_gemma":[0.0005241459,0.0001438359,0.002094195,0.00002188867,0.00001712922,0.00004574584,0.00001255951,0.00003100786,0.9062428,0.00003457518,0.09053612,0.0002960158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842219,0.0004144604,0.006216564,0.007644387,0.0001325958,0.0003431031,0.00002484376,0.0000402443,0.0009618452],"genre_scores_gemma":[0.9943115,0.00009839398,0.000862996,0.00411661,0.0002089972,0.00002517415,0.0001136251,0.00001676248,0.0002459803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08070116,"threshold_uncertainty_score":0.7538143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02571123766116009,"score_gpt":0.3149343357261614,"score_spread":0.2892230980650013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}