{"id":"W1993916481","doi":"10.1002/cbic.200300909","title":"Enantiocomplementary Enzymatic Resolution of the Chiral Auxiliary: <i>cis</i>,<i>cis</i>‐6‐(2,2‐Dimethylpropanamido)spiro[4.4]nonan‐1‐ol and the Molecular Basis for the High Enantioselectivity of Subtilisin Carlsberg","year":2004,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Steric effects; Stereochemistry; Oxyanion hole; Enantiomer; Kinetic resolution; Subtilisin; Enantioselective synthesis; Residue (chemistry); Active site; Catalysis; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002624111,0.0004435858,0.0001990764,0.0001281521,0.0001058265,0.0002799794,0.000342587,0.0002118623,0.0009130316],"category_scores_gemma":[0.0002216642,0.0001750268,0.0001601749,0.0001239907,0.000166308,0.0001924432,0.0002263634,0.0005812337,0.0005000134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002501333,"about_ca_system_score_gemma":0.0002547913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005536081,"about_ca_topic_score_gemma":0.000764099,"domain_scores_codex":[0.9998223,0.00004024949,0.0000136341,0.00003165021,0.00003586739,0.00005633528],"domain_scores_gemma":[0.9998955,0.0000150314,0.0000319236,0.00001883649,0.00001709311,0.00002170694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006564207,0.00001799495,0.00008124907,0.00002266432,0.000003600363,0.00009868572,0.00001913993,0.0001443585,0.9977952,0.000368078,0.00005138007,0.001332049],"study_design_scores_gemma":[0.000008152097,0.00006939592,0.0002532896,0.00000189906,0.000002857412,0.00008512253,0.000007670348,0.0004261841,0.9981204,0.00004734544,0.0009734741,0.00000412514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871179,0.0004726354,0.006191323,0.0001436422,0.00004544408,0.00002829915,0.000182294,0.0001471907,0.005671181],"genre_scores_gemma":[0.9931353,0.0003428563,0.003984384,0.00004506463,0.000007410295,0.00001489374,0.0002605656,0.00003673531,0.002172753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009130316,"threshold_uncertainty_score":0.00305438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005859062986704717,"score_gpt":0.2184380105529098,"score_spread":0.2125789475662051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}