{"id":"W1993916481","doi":"10.1002/cbic.200300909","title":"Enantiocomplementary Enzymatic Resolution of the Chiral Auxiliary: <i>cis</i>,<i>cis</i>‐6‐(2,2‐Dimethylpropanamido)spiro[4.4]nonan‐1‐ol and the Molecular Basis for the High Enantioselectivity of Subtilisin Carlsberg","year":2004,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Steric effects; Stereochemistry; Oxyanion hole; Enantiomer; Kinetic resolution; Subtilisin; Enantioselective synthesis; Residue (chemistry); Active site; Catalysis; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008008601,0.0002504406,0.0003472495,0.0000353036,0.0002538993,0.00002263894,0.0004657384,0.0001386718,0.000005553636],"category_scores_gemma":[0.0003377562,0.0001387337,0.0003396007,0.0003215003,0.0006390839,0.00001286493,0.0002403466,0.0001231648,3.67097e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003943135,"about_ca_system_score_gemma":0.0001422659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004242081,"about_ca_topic_score_gemma":0.0001437289,"domain_scores_codex":[0.9983873,0.0001335376,0.000498037,0.0004143123,0.0002761459,0.0002906508],"domain_scores_gemma":[0.9984022,0.0001110773,0.0003813801,0.0008409086,0.0002221069,0.00004232429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002594828,0.000123321,0.0001687696,0.0001252206,0.0002088137,1.662459e-7,0.0001813163,0.0002631534,0.9942067,0.003618093,0.0003896636,0.0004552879],"study_design_scores_gemma":[0.002143495,0.000164185,0.001771354,0.00005670411,0.000284772,0.000007053174,0.0001595913,0.0001737547,0.9930074,0.0009308078,0.001133799,0.000167122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984173,0.00466819,0.008446953,0.001092181,0.0001603392,0.001244938,0.00009011704,0.000008792001,0.0001155087],"genre_scores_gemma":[0.9983813,0.0002953789,0.0004548579,0.0002985327,0.0001002987,0.0001426334,0.0001430908,0.00003193544,0.0001520343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01420826,"threshold_uncertainty_score":0.5657394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005859062986704717,"score_gpt":0.2184380105529098,"score_spread":0.2125789475662051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}