{"id":"W1993917927","doi":"10.1038/nrd3011","title":"Therapeutic potential of complement modulation","year":2009,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":220,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Complement system; Homing (biology); Immunology; Acquired immune system; Immune modulation; Haematopoiesis; Immune system; Pathological; Stem cell; Medicine; Innate immune system; Complement receptor; Bone marrow; Biology; Neuroscience; Pathology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006964572,0.0007104317,0.003652264,0.0002782696,0.000108162,0.00003831852,0.0007626205,0.0006485239,0.000637894],"category_scores_gemma":[0.00006220712,0.0004975977,0.001819019,0.0003366336,0.00009517893,0.0001843055,0.0001705166,0.0009499982,0.0003774096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001697955,"about_ca_system_score_gemma":0.0002080879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001051785,"about_ca_topic_score_gemma":0.000007611916,"domain_scores_codex":[0.995366,0.001504985,0.001916669,0.0006535086,0.0001407303,0.0004181493],"domain_scores_gemma":[0.9969506,0.0001816414,0.001731004,0.001034736,0.00007448566,0.00002753889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000120617,0.0002001114,0.000004419855,0.01796627,0.0004841864,0.000002291149,0.00001324995,0.000001473999,0.00003759317,0.001378418,0.02128323,0.9586167],"study_design_scores_gemma":[0.0002995333,0.00003958853,0.00004466863,0.0208139,0.002017144,0.00003276697,0.000009098841,5.097191e-7,0.000007858012,0.0001447326,0.9761758,0.0004144375],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000007468309,0.9941306,0.0001214577,0.00002929198,0.001452549,0.00335899,0.0005156048,0.00004352043,0.0003405472],"genre_scores_gemma":[0.001442716,0.9934521,0.00003265815,0.0000984868,0.0001680431,0.000169146,0.003482469,0.00004710959,0.001107245],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9582022,"threshold_uncertainty_score":0.9997476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03567878474329839,"score_gpt":0.3480557263265099,"score_spread":0.3123769415832116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}