{"id":"W1993917927","doi":"10.1038/nrd3011","title":"Therapeutic potential of complement modulation","year":2009,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":220,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Complement system; Homing (biology); Immunology; Acquired immune system; Immune modulation; Haematopoiesis; Immune system; Pathological; Stem cell; Medicine; Innate immune system; Complement receptor; Bone marrow; Biology; Neuroscience; Pathology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007689712,0.001295869,0.001519991,0.00162778,0.0002898238,0.001081364,0.0009767853,0.0015431,0.003277212],"category_scores_gemma":[0.0007478241,0.0002852524,0.0005456034,0.001084354,0.0007865282,0.001347056,0.0008131693,0.002935669,0.001782024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008568076,"about_ca_system_score_gemma":0.0008979504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007880597,"about_ca_topic_score_gemma":0.001664436,"domain_scores_codex":[0.9998078,0.00003093006,0.00002003471,0.00003613949,0.00007923548,0.00002592869],"domain_scores_gemma":[0.9997428,0.0001208909,0.00002457615,0.00001124954,0.00007103238,0.00002951594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002164756,0.0001204493,0.0001182457,0.006127904,0.0001014675,0.0003088149,0.00002891783,0.0004907185,0.005948081,0.008641005,0.06473302,0.9131649],"study_design_scores_gemma":[0.00009624318,0.0001373404,0.0004467031,0.001239097,0.0001108415,0.0009718624,0.00002466097,0.000262436,0.001263724,0.00473179,0.9906939,0.0000215039],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001629891,0.9960306,0.0003266811,0.0006495628,0.0009108276,0.000006836238,0.0000178875,0.00001098215,0.001883511],"genre_scores_gemma":[0.001672169,0.9941274,0.000477966,0.0008988761,0.001128704,0.00001440724,0.00005314728,0.000002690512,0.001624496],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003277212,"threshold_uncertainty_score":0.01096338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03567878474329839,"score_gpt":0.3480557263265099,"score_spread":0.3123769415832116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}