{"id":"W1993929076","doi":"10.1016/j.cellsig.2008.01.006","title":"Targeting the TGFβ, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma","year":2008,"lang":"en","type":"review","venue":"Cellular Signalling","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Scleroderma Society of Ontario; Arthritis Society","keywords":"CTGF; Fibrosis; Scleroderma (fungus); Connective tissue; Transforming growth factor; Medicine; Pulmonary fibrosis; Growth factor; CYR61; Transforming growth factor beta; Connective tissue disease; Pathology; Immunology; Cancer research; Disease; Internal medicine; Autoimmune disease; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005130048,0.0004533911,0.0007858317,0.0001795129,0.0002094887,0.00007614078,0.0005745047,0.0003358789,0.00003476211],"category_scores_gemma":[0.0003189158,0.0003551219,0.0002615183,0.0002927358,0.0001181424,0.000003400031,0.0005092606,0.0005202874,0.00004913108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005945088,"about_ca_system_score_gemma":0.0001660325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005823332,"about_ca_topic_score_gemma":0.00001872926,"domain_scores_codex":[0.9973783,0.0004538411,0.000524073,0.0008107448,0.0002690924,0.000563876],"domain_scores_gemma":[0.9989052,0.0002278581,0.0001441818,0.0004749864,0.00008315598,0.0001645739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004034824,0.00008091643,0.0001435364,0.003635876,0.0002645417,0.0001095178,0.0003751604,0.00010746,0.3620985,0.00002286049,0.000435764,0.6326855],"study_design_scores_gemma":[0.0002280435,0.0001163907,0.000006122589,0.001720516,0.00005250652,0.00003255258,0.00004489336,0.00005514003,0.02200212,0.0000092939,0.975214,0.0005184194],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007017834,0.9903894,0.001250342,0.00003630626,0.00008693917,0.001072638,0.00004423032,0.0000137177,0.00008859984],"genre_scores_gemma":[0.01193584,0.9866863,0.0002133903,0.00004848773,0.0003638583,0.0001408257,0.0001834485,0.0001022511,0.0003255908],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9747782,"threshold_uncertainty_score":0.9998901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04431127601665104,"score_gpt":0.3026244317487418,"score_spread":0.2583131557320908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}