{"id":"W1993943685","doi":"10.1046/j.1468-2982.2003.00526.x","title":"Selective Decrease in Serotonin Synthesis Rate in Rat Brainstem Raphe Nuclei Following Chronic Administration of Low Doses of Amitriptyline: an Effect Compatible with an Anti-Migraine Effect","year":2003,"lang":"en","type":"article","venue":"Cephalalgia","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Ministerul Cercetării, Inovării şi Digitalizării","keywords":"Amitriptyline; Dorsal raphe nucleus; Serotonin; Autoreceptor; Thalamus; Medicine; Internal medicine; Endocrinology; Raphe; Anesthesia; Monoamine neurotransmitter; 5-HT receptor; Striatum; Raphe nuclei; Pharmacology; Serotonergic; Dopamine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001460348,0.0003798179,0.001268297,0.0004317092,0.00006861805,0.00001334829,0.0001109821,0.0001414203,0.0000377982],"category_scores_gemma":[0.0009160121,0.0002963343,0.0001884,0.001069608,0.0001289906,0.0002442499,0.00001652337,0.0002747761,0.000001960247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001529094,"about_ca_system_score_gemma":0.0004575873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002879179,"about_ca_topic_score_gemma":0.002758127,"domain_scores_codex":[0.9972038,0.0009902134,0.0006161964,0.0004761682,0.0002944885,0.0004190811],"domain_scores_gemma":[0.9983116,0.0007240889,0.0002433451,0.0004085263,0.0001144777,0.0001979156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003268509,0.001136994,0.6901218,0.002625831,0.0003131497,0.000260306,0.001767497,0.0001598882,0.2994406,0.00008847592,0.0001368316,0.0006800822],"study_design_scores_gemma":[0.007379586,0.00920598,0.2677208,0.002020707,0.0002581195,0.00002688357,0.0006135206,0.001115724,0.711333,0.000008497937,0.00002350418,0.0002936164],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99693,0.0006078541,0.00002339641,0.00003934978,0.00002705455,0.00174197,0.000008658054,0.00004072821,0.0005809881],"genre_scores_gemma":[0.9993309,0.00004435778,0.0002500028,0.00003615146,0.00003098334,0.0001510672,0.00004237477,0.00004874526,0.00006544357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.422401,"threshold_uncertainty_score":0.9999489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009140209578652242,"score_gpt":0.2776920737764199,"score_spread":0.2685518641977677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}