{"id":"W1993943685","doi":"10.1046/j.1468-2982.2003.00526.x","title":"Selective Decrease in Serotonin Synthesis Rate in Rat Brainstem Raphe Nuclei Following Chronic Administration of Low Doses of Amitriptyline: an Effect Compatible with an Anti-Migraine Effect","year":2003,"lang":"en","type":"article","venue":"Cephalalgia","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Ministerul Cercetării, Inovării şi Digitalizării","keywords":"Amitriptyline; Dorsal raphe nucleus; Serotonin; Autoreceptor; Thalamus; Medicine; Internal medicine; Endocrinology; Raphe; Anesthesia; Monoamine neurotransmitter; 5-HT receptor; Striatum; Raphe nuclei; Pharmacology; Serotonergic; Dopamine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044834,0.0002956666,0.0003949081,0.0001807504,0.00009103761,0.0001819942,0.0001498053,0.0002896763,0.00146505],"category_scores_gemma":[0.0001795932,0.000168365,0.0001370394,0.0001154492,0.0002620022,0.0002207185,0.000114293,0.0004746608,0.0003258571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001798439,"about_ca_system_score_gemma":0.000151666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009137479,"about_ca_topic_score_gemma":0.001957491,"domain_scores_codex":[0.9999268,0.00001374909,0.000006284085,0.00001511326,0.00001638133,0.00002164356],"domain_scores_gemma":[0.9998234,0.00003360653,0.00005189429,0.00002057671,0.00002317433,0.00004752487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00104667,0.00004081852,0.000305067,0.00004422871,0.00001181715,0.00004177292,0.00001683597,0.00001446225,0.9967458,0.00001418691,0.00002136677,0.00169696],"study_design_scores_gemma":[0.00009052515,0.006421437,0.02216678,0.00001165489,0.00006703071,0.0002946436,0.00005616141,0.0003257353,0.9694259,0.00002586169,0.001107263,0.000007142737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966366,0.002030057,0.0004807926,0.00004195278,0.00001474394,0.00001201469,0.0002332592,0.00003106545,0.0005194252],"genre_scores_gemma":[0.9942866,0.001805862,0.001053791,0.00005982249,0.00002906465,0.00005399483,0.0005759053,0.00001450373,0.002120549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00146505,"threshold_uncertainty_score":0.004901111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009140209578652242,"score_gpt":0.2776920737764199,"score_spread":0.2685518641977677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}