{"id":"W1993957411","doi":"10.1074/jbc.m804215200","title":"Ligand Binding to Truncated Hemoglobin N from Mycobacterium tuberculosis Is Strongly Modulated by the Interplay between the Distal Heme Pocket Residues and Internal Water","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Heme; Mycobacterium tuberculosis; Hemoglobin; Ligand (biochemistry); Chemistry; Hemeprotein; Tuberculosis; Biochemistry; Biophysics; Stereochemistry; Biology; Medicine; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002169235,0.0002343666,0.0002810209,0.00001509908,0.000179064,0.00005763509,0.0003612313,0.0002877398,0.00009723909],"category_scores_gemma":[0.00009438452,0.000104732,0.000154619,0.00006787994,0.0002034499,0.00001026882,0.000224039,0.0003414782,0.00000385723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003267281,"about_ca_system_score_gemma":0.00002265703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002786714,"about_ca_topic_score_gemma":0.000001015779,"domain_scores_codex":[0.9987357,0.00006974328,0.0004502759,0.000291308,0.0001733271,0.0002796168],"domain_scores_gemma":[0.9993045,0.00004057545,0.0001673422,0.0002286446,0.0001035026,0.0001553729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002660809,0.00002019329,0.02975242,0.000004572388,0.0001827236,0.000009925398,0.0001203384,0.00000201324,0.9608188,6.392276e-8,0.008471902,0.0003509495],"study_design_scores_gemma":[0.0004520369,0.0002791102,0.02916,0.00002314273,0.00004258181,0.0003123156,0.0001237728,0.000004249112,0.9626432,0.00003348282,0.006762235,0.0001638922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976142,0.0004475455,0.0001981587,0.001240508,0.0001236683,0.00008242333,0.0001915416,0.000007223881,0.00009475493],"genre_scores_gemma":[0.9981159,0.0001444033,0.00007385224,0.000469117,0.0007389563,0.000002980001,0.000213062,0.00001293149,0.0002287839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001824367,"threshold_uncertainty_score":0.4270846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052168388142822,"score_gpt":0.2392028037289975,"score_spread":0.2286811198475693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}