{"id":"W1993961540","doi":"10.1073/pnas.1303444110","title":"Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Ontario Ministry of Health and Long-Term Care; University Health Network","keywords":"Oxidative stress; Reactive oxygen species; Oxidative phosphorylation; In vivo; Biology; Mitochondrion; Endocrinology; Internal medicine; Mitochondrial biogenesis; Heart failure; Cell biology; Biochemistry; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000287203,0.000349536,0.0002757391,0.0006298507,0.0001821425,0.0003032372,0.0002437264,0.0003635892,0.0009295772],"category_scores_gemma":[0.0001380354,0.0002499081,0.0002050781,0.0001103165,0.0002969435,0.0002146005,0.0001359576,0.000594578,0.0003091782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002247148,"about_ca_system_score_gemma":0.0002511609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004333088,"about_ca_topic_score_gemma":0.000636094,"domain_scores_codex":[0.9998449,0.00003063424,0.00001842836,0.00003239477,0.00003278851,0.0000407788],"domain_scores_gemma":[0.9996322,0.00004497563,0.0001151467,0.00004038593,0.00003101226,0.0001363415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003149975,0.0001060116,0.0002275344,0.00002628891,0.00001054324,0.00004240022,0.00001679422,0.00008691617,0.9979808,0.0001010412,0.0000425604,0.001044118],"study_design_scores_gemma":[0.0001208035,0.002014969,0.005004637,0.00002010078,0.00004316028,0.0002240704,0.0000393128,0.001327597,0.9895651,0.0001670134,0.001465571,0.000007595521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950518,0.001387094,0.002180675,0.0001539856,0.00003862617,0.00002201012,0.0003721442,0.0001087729,0.0006849283],"genre_scores_gemma":[0.9937841,0.00103882,0.002134365,0.00006787922,0.00001409243,0.00003460843,0.0006528395,0.0000416826,0.002231613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009295772,"threshold_uncertainty_score":0.003109694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03691037389141202,"score_gpt":0.2996724059661567,"score_spread":0.2627620320747447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}