{"id":"W1993979920","doi":"10.1016/j.ymgme.2009.10.152","title":"135. Identification of pyrimethamine derivatives showing improved enzyme enhancement efficacy towards mutant Hex A","year":2010,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Hospital for Sick Children","funders":"","keywords":"Mutant; Pyrimethamine; Identification (biology); Chemistry; Enzyme; Pharmacology; Combinatorial chemistry; Biochemistry; Biology; Malaria; Plasmodium falciparum; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001575743,0.0003776637,0.0003666224,0.0002217155,0.0001552492,0.0003379728,0.000369251,0.0003564532,0.002202248],"category_scores_gemma":[0.000278682,0.0001997307,0.0004453275,0.0002635623,0.0002163022,0.0002072739,0.0002046466,0.0004092027,0.0007162683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003678728,"about_ca_system_score_gemma":0.0002738436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002331082,"about_ca_topic_score_gemma":0.001469697,"domain_scores_codex":[0.9998189,0.00003288968,0.00003369604,0.00002800302,0.00004659252,0.00003993495],"domain_scores_gemma":[0.9998447,0.00004882352,0.00003086599,0.00002472057,0.00002700938,0.00002382415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002655199,0.00006524031,0.0001481286,0.00002832557,0.000008554141,0.00007600984,0.000009272087,0.0001116313,0.9972925,0.0001195221,0.00007961875,0.001795683],"study_design_scores_gemma":[0.00001475329,0.0001828339,0.0007493229,0.000002199306,0.000009893299,0.000143112,0.000008884743,0.0003200009,0.9976949,0.00001965998,0.0008501795,0.000004296598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814802,0.0005995637,0.01094091,0.0002288687,0.00009055538,0.0001502755,0.002683934,0.0002663765,0.003559317],"genre_scores_gemma":[0.9845501,0.0002990187,0.008202646,0.00005373307,0.000008732837,0.00006589651,0.002998294,0.00006817287,0.003753403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002331082,"threshold_uncertainty_score":0.007367253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008389670307914973,"score_gpt":0.2665093716731211,"score_spread":0.2581197013652061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}