{"id":"W1993986699","doi":"10.1016/j.chembiol.2006.08.010","title":"A Small-Molecule Probe for Hepatitis C Virus Replication that Blocks Protein Folding","year":2006,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences; Plant Biotechnology Institute; National Research Council Canada; Steacie Institute for Molecular Sciences; University of Ottawa","funders":"","keywords":"Biology; Hepatitis C virus; Replicon; Subgenomic mRNA; Viral replication; Small molecule; Computational biology; Cell biology; Folding (DSP implementation); Virology; Virus; Genome; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002246225,0.0002213406,0.0002182693,0.00002076664,0.0001232105,0.00002588416,0.0002428028,0.0003427384,0.00003616962],"category_scores_gemma":[0.0001495879,0.0002221748,0.0001672779,0.00006978518,0.0001108965,0.00000223538,0.00009161629,0.00009791685,0.00000437072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002037938,"about_ca_system_score_gemma":0.00005831294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002887984,"about_ca_topic_score_gemma":0.00004846649,"domain_scores_codex":[0.9985626,0.00003029625,0.0002642337,0.0007192962,0.00005360537,0.0003699703],"domain_scores_gemma":[0.9990306,0.0000151958,0.0001647162,0.0006130893,0.0001101267,0.00006626303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006903407,0.0000633477,0.001738174,0.00004538984,0.00002714372,0.000001059096,0.00000520296,0.000003539279,0.9956631,0.0001267641,0.001169234,0.001088029],"study_design_scores_gemma":[0.0005173252,0.00009196231,0.0002521327,0.00001504523,0.00002610778,0.0000189097,0.000004840126,0.0000599108,0.944164,0.0006511815,0.0539412,0.0002573982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812583,0.001396133,0.0155036,0.000196634,0.00008140421,0.0004714424,0.0000886076,0.00005566359,0.0009482111],"genre_scores_gemma":[0.9923968,0.00006545535,0.002300961,0.0001364986,0.0008002367,0.0004398216,0.001194848,0.00003970182,0.00262567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05277197,"threshold_uncertainty_score":0.9060025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01766640650355255,"score_gpt":0.2486343708823469,"score_spread":0.2309679643787943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}