{"id":"W1993998711","doi":"10.2147/dddt.s19931","title":"Flavonoids targeting of I&amp;kappa;B phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells","year":2011,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Flavonoids in Medical Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Neuroinflammation; Phosphorylation; Signal transduction; Luteolin; Matrix metalloproteinase; Blood–brain barrier; Downregulation and upregulation; Chemistry; Cell biology; Pharmacology; Apigenin; Cancer research; Biochemistry; Biology; Inflammation; Immunology; Endocrinology; Flavonoid; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001572327,0.0002084774,0.0003547147,0.0002272391,0.0001258221,0.00001555685,0.0001122925,0.0001360164,0.0002143311],"category_scores_gemma":[0.0001410643,0.0001692567,0.00003091327,0.0001786931,0.0001388398,0.00008421332,0.00005919347,0.0002793191,0.000006287426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005150693,"about_ca_system_score_gemma":0.0001701635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007963476,"about_ca_topic_score_gemma":0.000008615681,"domain_scores_codex":[0.9981983,0.0001994632,0.0004687419,0.0003518073,0.0004309613,0.0003507228],"domain_scores_gemma":[0.9991737,0.0002871617,0.0001051271,0.0001612739,0.00008243006,0.0001902961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004725807,0.000141186,0.0141194,0.00006566002,0.0000281842,0.00001292447,0.01391728,3.6132e-7,0.944313,0.00003408456,0.0003369052,0.02655841],"study_design_scores_gemma":[0.002883425,0.0001607674,0.01777352,0.0002000082,0.00000474009,0.000001275848,0.0003839144,0.00005723082,0.9769611,0.0003707723,0.001028994,0.0001741841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963157,0.001300087,0.001145499,0.00007812588,0.00006351899,0.000696324,0.000001334006,0.0000299784,0.0003694037],"genre_scores_gemma":[0.972613,0.0005595269,0.02600702,0.0001159576,0.00004842249,0.00005125506,0.0000182663,0.00003166205,0.0005548466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03264814,"threshold_uncertainty_score":0.690209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07462496248851534,"score_gpt":0.3088408561781034,"score_spread":0.2342158936895881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}