{"id":"W1993998711","doi":"10.2147/dddt.s19931","title":"Flavonoids targeting of I&amp;kappa;B phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells","year":2011,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Flavonoids in Medical Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Neuroinflammation; Phosphorylation; Signal transduction; Luteolin; Matrix metalloproteinase; Blood–brain barrier; Downregulation and upregulation; Chemistry; Cell biology; Pharmacology; Apigenin; Cancer research; Biochemistry; Biology; Inflammation; Immunology; Endocrinology; Flavonoid; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011711,0.0002933731,0.0001928594,0.0001539753,0.0001060957,0.0001365587,0.0001375659,0.0001614465,0.001642361],"category_scores_gemma":[0.00008376496,0.00009602455,0.0002288145,0.00009042703,0.0001589611,0.0001474798,0.0000982863,0.0005201714,0.0002651244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001415016,"about_ca_system_score_gemma":0.0001981309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007069231,"about_ca_topic_score_gemma":0.001003797,"domain_scores_codex":[0.9999348,0.000009225117,0.000006834179,0.00001338171,0.00001153981,0.00002418739],"domain_scores_gemma":[0.999957,0.00000692697,0.00001223164,0.000006446285,0.000005160403,0.00001231502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002599156,0.00009197473,0.00004911357,0.00003787772,0.000004856108,0.00002101911,0.000009332833,0.00003053069,0.998405,0.00002953706,0.00003613349,0.001024601],"study_design_scores_gemma":[0.00006428095,0.001218225,0.003965123,0.00001001993,0.00002409419,0.0001741895,0.00003112491,0.0005126049,0.9921142,0.00004052699,0.001841931,0.000003624478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943582,0.002150791,0.001819188,0.0001278301,0.00004687269,0.00003940719,0.0002890119,0.00004917868,0.001119633],"genre_scores_gemma":[0.9958098,0.001115644,0.001047797,0.00004976397,0.00001503965,0.00004528538,0.000340931,0.000007532175,0.001568175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642361,"threshold_uncertainty_score":0.005494177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07462496248851534,"score_gpt":0.3088408561781034,"score_spread":0.2342158936895881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}