{"id":"W1994017393","doi":"10.1128/aac.03359-14","title":"Pharmacokinetics, Safety, and Tolerability of Faldaprevir in Patients with Renal Impairment","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Medicine; Renal function; Pharmacokinetics; Adverse effect; Tolerability; Internal medicine; Hepatitis C; Gastroenterology; Urology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008214156,0.0002044104,0.0005716558,0.0001735847,0.0001811816,0.0003607393,0.00009075756,0.000198048,0.0007852269],"category_scores_gemma":[0.002229111,0.0001054213,0.0003052738,0.0002811261,0.0001561833,0.0002511006,0.0001355558,0.0004176041,0.0002219205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407005,"about_ca_system_score_gemma":0.0002574413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007033307,"about_ca_topic_score_gemma":0.0007862201,"domain_scores_codex":[0.9996576,0.0001549483,0.00003680994,0.00003929849,0.00006640553,0.00004494256],"domain_scores_gemma":[0.9991887,0.0002851885,0.0002808404,0.00004184276,0.00008053136,0.0001228098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.04485503,0.002073189,0.7670525,0.0003721667,0.0006823342,0.001384074,0.0005850319,0.001626375,0.01987131,0.0001293005,0.001669284,0.1596994],"study_design_scores_gemma":[0.001927566,0.03444667,0.9526928,0.00005558681,0.0003759007,0.002357224,0.0002133933,0.002257063,0.002977003,0.0001994865,0.002461453,0.00003586392],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976548,0.001080895,0.0002318367,0.00009069397,0.000006053952,0.00003173624,0.000120365,0.00001394753,0.0007696998],"genre_scores_gemma":[0.9991199,0.0002975922,0.000178432,0.0001179069,0.00001904267,0.0000181724,0.0001116402,0.000002356731,0.0001349768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008214156,"threshold_uncertainty_score":0.004344106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008117181534174088,"score_gpt":0.2626180718196328,"score_spread":0.2545008902854587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}