{"id":"W1994029368","doi":"10.1016/j.stem.2010.06.024","title":"Female Human iPSCs Retain an Inactive X Chromosome","year":2010,"lang":"en","type":"article","venue":"Cell stem cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":285,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; XIST; Reprogramming; Induced pluripotent stem cell; X-inactivation; Epigenome; Chromatin; Embryonic stem cell; X chromosome; Genetics; Cell biology; Gene; Gene expression; DNA methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001173126,0.0001692908,0.0001250021,0.00003007435,0.0000939688,0.00002837284,0.0002234568,0.0001929227,0.00006556047],"category_scores_gemma":[0.00000226357,0.0001749303,0.0000687135,0.00005446515,0.00004350902,0.000003910906,0.00008354365,0.0001897412,0.00004841802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008702104,"about_ca_system_score_gemma":0.00003364322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001148405,"about_ca_topic_score_gemma":0.00005841976,"domain_scores_codex":[0.9991088,0.00002423896,0.00014848,0.0003631376,0.00009009592,0.0002652721],"domain_scores_gemma":[0.9992505,0.000005316479,0.00004808079,0.0005120645,0.00004207859,0.0001419703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007028149,0.00007659852,0.0005201118,0.00003427926,0.000005796061,0.000005241943,0.0001592265,0.00006904895,0.9982873,0.00002859964,0.0002890484,0.0005177251],"study_design_scores_gemma":[0.0003278477,0.0002462801,0.0006670842,0.00000278562,0.00001194899,0.000006065516,0.0003117181,0.00007827277,0.9679196,0.00001389091,0.03017891,0.0002355895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755421,0.0003158555,0.0007472853,0.000007829814,0.0002350661,0.0001429286,0.000009424559,0.00002564883,0.02297391],"genre_scores_gemma":[0.9928519,0.00002429578,0.0004722882,0.00004245397,0.0003659492,0.0000139082,0.0001009466,0.00003796848,0.006090259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03036769,"threshold_uncertainty_score":0.7133451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007728200562446661,"score_gpt":0.2706212013959752,"score_spread":0.2628930008335286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}