{"id":"W1994029368","doi":"10.1016/j.stem.2010.06.024","title":"Female Human iPSCs Retain an Inactive X Chromosome","year":2010,"lang":"en","type":"article","venue":"Cell stem cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":285,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; XIST; Reprogramming; Induced pluripotent stem cell; X-inactivation; Epigenome; Chromatin; Embryonic stem cell; X chromosome; Genetics; Cell biology; Gene; Gene expression; DNA methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002665246,0.0004727501,0.0003505764,0.0005411911,0.0003499532,0.000645745,0.0004332652,0.0007979266,0.009055239],"category_scores_gemma":[0.0001722541,0.0002927467,0.0003193625,0.0002159951,0.0004642163,0.0003580333,0.0004720711,0.0009564447,0.004336644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002246176,"about_ca_system_score_gemma":0.0002495711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003636655,"about_ca_topic_score_gemma":0.0005696613,"domain_scores_codex":[0.999786,0.00001794727,0.00002597808,0.00005680495,0.00007291132,0.00004041156],"domain_scores_gemma":[0.9997905,0.00004501176,0.00004371194,0.00006100106,0.00001984209,0.00003995057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009274993,0.00002941217,0.0006096459,0.00002911007,0.000009830012,0.0003770352,0.00004837123,0.00006688476,0.9905833,0.001784159,0.0004130853,0.005956618],"study_design_scores_gemma":[0.00001997964,0.00004819014,0.003592191,0.000007628708,0.0000208158,0.001187925,0.0000401483,0.0002869397,0.9779482,0.0002166744,0.01662332,0.000008017784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9131646,0.001339121,0.03671389,0.001005284,0.000474903,0.0001607093,0.007979283,0.001649711,0.03751254],"genre_scores_gemma":[0.9096547,0.0007219089,0.005961207,0.0002398553,0.00005338675,0.0001206932,0.003827282,0.0004571156,0.07896386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009055239,"threshold_uncertainty_score":0.03029275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007728200562446661,"score_gpt":0.2706212013959752,"score_spread":0.2628930008335286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}