{"id":"W1994057134","doi":"10.1074/jbc.m401312200","title":"Menin Is Required for Bone Morphogenetic Protein 2- and Transforming Growth Factor β-regulated Osteoblastic Differentiation through Interaction with Smads and Runx2","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"RUNX2; Transforming growth factor; Bone morphogenetic protein 2; Bone morphogenetic protein; Osteoblast; Transforming growth factor beta; Cell biology; Chemistry; Cancer research; Bone morphogenetic protein 7; Biology; Biochemistry; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007251866,0.0001675747,0.0002076738,0.00001584183,0.00007686283,0.00003012671,0.00007203336,0.0001846045,0.00001278947],"category_scores_gemma":[0.0001194995,0.0001149224,0.00007172277,0.00003912503,0.0001064613,0.00001388992,0.00002405229,0.0001127554,1.283802e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002585481,"about_ca_system_score_gemma":0.0000490295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001861745,"about_ca_topic_score_gemma":7.321596e-7,"domain_scores_codex":[0.9991836,0.00002016799,0.0003148006,0.0002210299,0.0001009497,0.0001594465],"domain_scores_gemma":[0.9994269,0.00002446345,0.0002504035,0.00007606435,0.0001278061,0.00009436259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008807812,0.00007554956,0.0005965728,0.0001001294,0.00007998248,0.000004498731,0.00007847526,0.00001849574,0.9977036,0.000002484708,0.000007251734,0.0004522041],"study_design_scores_gemma":[0.001736086,0.000884073,0.002150035,0.0001604231,0.00005090276,0.0001631271,0.00008237376,0.00001249189,0.9941783,0.0002846778,0.0001380745,0.0001594604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916838,0.0009628973,0.006951309,0.0001541925,0.00002040732,0.0001865362,0.00002509838,0.000007088188,0.000008694285],"genre_scores_gemma":[0.9976003,0.00007641115,0.002060752,0.00003710933,0.0001304667,0.00001492335,0.00003951272,0.00001305054,0.00002743796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00591656,"threshold_uncertainty_score":0.46864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725667082054758,"score_gpt":0.2447462787092468,"score_spread":0.2274896078886992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}