{"id":"W1994094375","doi":"10.1097/qco.0b013e3283298f1f","title":"Management of paediatric HIV-1 resistance","year":2009,"lang":"en","type":"review","venue":"Current Opinion in Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Wellcome Trust; Gilead Sciences; Bristol-Myers Squibb","keywords":"Medicine; Darunavir; Drug resistance; Transmission (telecommunications); Clinical trial; Pre-exposure prophylaxis; Intensive care medicine; Antiretroviral therapy; Human immunodeficiency virus (HIV); Viral load; Virology; Internal medicine; Men who have sex with men","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009849352,0.0005027535,0.001611432,0.0007707402,0.00004872532,0.00001706771,0.000138949,0.0001295311,0.0001080543],"category_scores_gemma":[0.00003112597,0.0004134098,0.0006167673,0.001042995,0.00005200753,0.00005520936,0.00007489064,0.0002514186,0.0002028574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004576275,"about_ca_system_score_gemma":0.0003189439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.19312e-7,"about_ca_topic_score_gemma":5.678997e-7,"domain_scores_codex":[0.9976801,0.0001102207,0.0009382396,0.0005349366,0.0004052964,0.0003312342],"domain_scores_gemma":[0.9987633,0.00009801771,0.0004215327,0.000461662,0.00006403403,0.0001914024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002934116,0.001589851,0.00431372,0.1041428,0.0002940891,0.00002896145,0.00002234965,5.517294e-7,6.665316e-10,0.0006755373,0.02573486,0.8631679],"study_design_scores_gemma":[0.001190469,0.00003963603,0.001853192,0.06724498,0.001460994,0.000008868567,0.000007851812,4.719861e-7,3.183994e-8,0.0001488539,0.9277372,0.0003073907],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000005342096,0.9938154,0.00001964612,0.00003968079,0.001779223,0.001673499,0.0001441432,0.0001051708,0.002417903],"genre_scores_gemma":[0.00004047918,0.9959574,0.00006498143,0.000002789276,0.0003492546,0.0004302258,0.001366282,0.00004125538,0.001747382],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9020024,"threshold_uncertainty_score":0.9998318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04017794438014056,"score_gpt":0.3611123458241983,"score_spread":0.3209344014440577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}