{"id":"W1994108540","doi":"10.1080/14660820310006689","title":"A prospective, randomized, placebo‐controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: feasibility and results","year":2003,"lang":"en","type":"article","venue":"Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Magnetic resonance imaging; Placebo; Creatine; Medicine; Premotor cortex; Superior parietal lobule; Surrogate endpoint; Functional magnetic resonance imaging; Nuclear medicine; Internal medicine; Anesthesia; Pathology; Radiology; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00492952,0.002526465,0.003936749,0.000639216,0.0009355355,0.001142633,0.001308297,0.003073167,0.002882862],"category_scores_gemma":[0.004707892,0.001224849,0.001577677,0.0006250946,0.002506177,0.001164695,0.000570819,0.002592133,0.0009506217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000638444,"about_ca_system_score_gemma":0.002061319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009943419,"about_ca_topic_score_gemma":0.00165455,"domain_scores_codex":[0.9971234,0.001678744,0.0002837575,0.000398009,0.0002438008,0.0002723396],"domain_scores_gemma":[0.9966349,0.0008439668,0.001035824,0.0004520482,0.0003217866,0.0007115814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9855794,0.006281471,0.000301423,0.0001260407,0.0002620315,0.00001716594,0.00002668364,0.00009248114,0.00305464,0.00003742942,0.0001105698,0.004110677],"study_design_scores_gemma":[0.821608,0.1756616,0.00134028,0.000009273541,0.000220218,0.00001819075,0.00001072102,0.0002026576,0.0006634116,0.00005536478,0.0001976325,0.00001272646],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845932,0.001757779,0.001353679,0.0003303958,0.0004450375,0.009952562,0.0006657971,0.0001253765,0.0007761185],"genre_scores_gemma":[0.9757805,0.001280749,0.004016235,0.0006115462,0.000526787,0.01552503,0.0007505325,0.00004000296,0.001468548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00492952,"threshold_uncertainty_score":0.02607012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04979337902546877,"score_gpt":0.2906431442193888,"score_spread":0.24084976519392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}