{"id":"W1994127134","doi":"10.1021/jm030544m","title":"Design and Synthesis of 3‘- and 5‘-<i>O</i>-(3-Benzenesulfonylfuroxan-4-yl)-2‘-deoxyuridines:  Biological Evaluation as Hybrid Nitric Oxide Donor−Nucleoside Anticancer Agents","year":2004,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Nitric oxide; Cytotoxicity; Nucleoside; Moiety; Thymidine kinase; Cell culture; Cytotoxic T cell; Transfection; Nucleoside analogue; Cysteine; Stereochemistry; Herpes simplex virus; Biochemistry; Enzyme; In vitro; Virus; Gene; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001798803,0.0002312397,0.0007083133,0.0001383223,0.00005372709,0.00001227908,0.0001188108,0.00013855,0.0001003051],"category_scores_gemma":[0.002853272,0.0001635478,0.0001131415,0.0002045911,0.0002226471,0.00009672048,0.0000396506,0.0003614042,0.000002812798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001273869,"about_ca_system_score_gemma":0.0004139447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003401177,"about_ca_topic_score_gemma":1.166138e-7,"domain_scores_codex":[0.9979137,0.000100062,0.0007035452,0.0002396856,0.0007922326,0.0002508237],"domain_scores_gemma":[0.9978714,0.0006701457,0.0005384603,0.0001820791,0.0003950178,0.0003429252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001530319,0.0003270225,0.007162025,0.000560099,0.0002632794,0.0005576701,0.0000865655,0.0001422846,0.9756679,0.000004642138,0.0003389925,0.01335922],"study_design_scores_gemma":[0.007466462,0.0007883323,0.02542334,0.001698281,0.001273288,0.007529352,0.0003593852,0.0003446747,0.9536058,0.001135625,0.0001575592,0.0002178409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934992,0.004400244,0.0007337786,0.0006712895,0.00005760455,0.0002410073,0.000002758792,0.00001176898,0.0003824052],"genre_scores_gemma":[0.9930179,0.003294968,0.002964448,0.0003096838,0.0003611476,0.00000803253,0.000001969942,0.0000207709,0.00002106044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02206203,"threshold_uncertainty_score":0.6669287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03495388679923781,"score_gpt":0.3038522561739988,"score_spread":0.268898369374761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}