{"id":"W1994127134","doi":"10.1021/jm030544m","title":"Design and Synthesis of 3‘- and 5‘-<i>O</i>-(3-Benzenesulfonylfuroxan-4-yl)-2‘-deoxyuridines:  Biological Evaluation as Hybrid Nitric Oxide Donor−Nucleoside Anticancer Agents","year":2004,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Nitric oxide; Cytotoxicity; Nucleoside; Moiety; Thymidine kinase; Cell culture; Cytotoxic T cell; Transfection; Nucleoside analogue; Cysteine; Stereochemistry; Herpes simplex virus; Biochemistry; Enzyme; In vitro; Virus; Gene; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002301415,0.0003932356,0.0003549982,0.0001510054,0.0001134426,0.0002723495,0.0005196941,0.000503896,0.0007464322],"category_scores_gemma":[0.0001472097,0.0002463197,0.0002998341,0.0001859541,0.0001549225,0.0002501462,0.0001981326,0.0003449354,0.0003924297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000290774,"about_ca_system_score_gemma":0.0002212239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002574796,"about_ca_topic_score_gemma":0.0005551528,"domain_scores_codex":[0.9998804,0.00002239215,0.00001369225,0.00003474673,0.00002694989,0.00002171278],"domain_scores_gemma":[0.9998933,0.000008770595,0.00003554277,0.000008980794,0.00002306578,0.00003030102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008772093,0.00005162945,0.00008639925,0.0001175413,0.00001288141,0.00006800991,0.00002818743,0.0005420843,0.9950253,0.0003793337,0.00004596228,0.003554716],"study_design_scores_gemma":[0.00005872683,0.001039382,0.000444145,0.000007922205,0.00002773369,0.0001872466,0.00001347742,0.001020692,0.9909083,0.00005705935,0.006223321,0.00001195654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560216,0.005100661,0.03279161,0.0001180193,0.00009821364,0.0004856638,0.0005357455,0.0001656332,0.004682721],"genre_scores_gemma":[0.9396403,0.003106371,0.05161162,0.0001227074,0.000023723,0.0003931145,0.0006497723,0.00003591826,0.004416415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007464322,"threshold_uncertainty_score":0.002497077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03495388679923781,"score_gpt":0.3038522561739988,"score_spread":0.268898369374761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}