{"id":"W1994144105","doi":"10.1242/dev.01801","title":"Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst","year":2005,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1141,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Synchrotron Light Research Institute; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Inner cell mass; Biology; Blastocyst; Homeobox protein NANOG; Cell biology; Trophoblast; Blastocoel; Nanog Homeobox Protein; Embryo; Embryonic stem cell; CDX2; Transcription factor; Genetics; Homeobox; Embryogenesis; SOX2; Placenta; Gene; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001853179,0.00007229509,0.00007362973,0.00004010343,0.00003947825,0.00001225465,0.0001102816,0.0000493729,0.000007202975],"category_scores_gemma":[0.00001380793,0.00005662375,0.00002093813,0.00004749345,0.00002156939,0.000002970802,0.00003662323,0.00003130876,0.000004051166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002534792,"about_ca_system_score_gemma":0.00004135004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003239065,"about_ca_topic_score_gemma":0.00003907292,"domain_scores_codex":[0.9993452,0.00003414198,0.0001854258,0.0001794869,0.0001242304,0.0001314968],"domain_scores_gemma":[0.9997186,0.00001348744,0.00006044333,0.0001414908,0.00004542616,0.00002054401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000893083,0.00008792221,0.00104567,0.00003826111,0.00001036105,1.579255e-7,0.0007950423,0.00002598372,0.9888996,0.00000667911,0.00122741,0.007773533],"study_design_scores_gemma":[0.0005748804,0.00005637143,0.01717085,0.0000052357,0.000002874428,0.000001107659,0.00009892156,0.0003451032,0.9560768,0.00000517905,0.0255904,0.00007229458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940947,0.0001583472,0.004788721,0.0002492197,0.00001948151,0.00041359,0.000008763268,0.000002368254,0.000264866],"genre_scores_gemma":[0.9966102,0.000139911,0.001891629,0.00006549538,0.00003236716,0.0000725518,0.0001384384,0.000008032638,0.001041358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03282289,"threshold_uncertainty_score":0.230905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02148918862219947,"score_gpt":0.2563346981636353,"score_spread":0.2348455095414358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}