{"id":"W1994144105","doi":"10.1242/dev.01801","title":"Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst","year":2005,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1141,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Synchrotron Light Research Institute; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Inner cell mass; Biology; Blastocyst; Homeobox protein NANOG; Cell biology; Trophoblast; Blastocoel; Nanog Homeobox Protein; Embryo; Embryonic stem cell; CDX2; Transcription factor; Genetics; Homeobox; Embryogenesis; SOX2; Placenta; Gene; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001409684,0.0004828962,0.0002233282,0.0002944149,0.000269836,0.0005525129,0.0002247798,0.0003756238,0.001913809],"category_scores_gemma":[0.0001962318,0.000389745,0.0001424688,0.0001409132,0.0002920793,0.0002349597,0.0003966229,0.0004445113,0.0009494757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003473255,"about_ca_system_score_gemma":0.0002830334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006030297,"about_ca_topic_score_gemma":0.0009615609,"domain_scores_codex":[0.9997606,0.00002514542,0.00003002824,0.00005838038,0.00008170116,0.00004412456],"domain_scores_gemma":[0.9998018,0.00002245122,0.00006008494,0.00002391345,0.00001854258,0.00007314865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007048068,0.00001176431,0.0003948282,0.00002569881,0.000002945539,0.0001554425,0.000009646011,0.00005160481,0.9984804,0.0001380936,0.00004111259,0.0006178968],"study_design_scores_gemma":[0.00005042106,0.0000834024,0.01722095,0.00001230562,0.00001592744,0.0008173261,0.00003312861,0.0008961675,0.9758369,0.0001000004,0.00492762,0.000005947904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890428,0.001706872,0.003505941,0.0001550422,0.00004901437,0.00002496969,0.001011902,0.0001832633,0.004320185],"genre_scores_gemma":[0.9840267,0.0007352751,0.002020279,0.00006129744,0.00001321897,0.00003883386,0.001939357,0.00009093885,0.01107413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001913809,"threshold_uncertainty_score":0.006402373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02148918862219947,"score_gpt":0.2563346981636353,"score_spread":0.2348455095414358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}