{"id":"W1994201257","doi":"10.1016/j.bbadis.2015.01.019","title":"Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation","year":2015,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research; National Institute of General Medical Sciences; National Natural Science Foundation of China","keywords":"Calpain; Endoplasmic reticulum; Calpastatin; Unfolded protein response; Apoptosis; Cell biology; Chemistry; Hypoxia (environmental); Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004407215,0.0003696926,0.0003654716,0.0002398592,0.00006952711,0.00006076884,0.0002991261,0.0002143987,0.000004080485],"category_scores_gemma":[0.0004827069,0.0003762373,0.0004658301,0.0004298082,0.0001159775,0.00003138922,0.0002023049,0.0001640708,0.000005172281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006507483,"about_ca_system_score_gemma":0.0003483941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005193178,"about_ca_topic_score_gemma":0.000007104287,"domain_scores_codex":[0.9973811,0.0004115005,0.0005240737,0.0007314793,0.0005624454,0.0003894361],"domain_scores_gemma":[0.99845,0.0000234066,0.0002990842,0.0006318795,0.0001960477,0.0003995634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003371824,0.0003741108,0.0001884312,0.00009184507,0.000178118,0.000009284192,0.0001941059,0.0002591261,0.9977737,0.00004419601,0.0001630735,0.0003868483],"study_design_scores_gemma":[0.001351263,0.0002083537,0.004484325,0.0001373347,0.0001554346,0.00000156127,0.0002366492,0.000499204,0.9922826,0.0001209592,0.0001009099,0.0004213867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969736,0.0002918729,0.0003562198,0.00113773,0.000247108,0.000681303,0.00009066692,0.00004209071,0.0001793874],"genre_scores_gemma":[0.9982628,0.00003991339,0.0004500049,0.000222381,0.0001455812,0.000114306,0.0006637491,0.00006307469,0.00003816053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00549106,"threshold_uncertainty_score":0.9998689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123737471591121,"score_gpt":0.2441937139063323,"score_spread":0.2329563391904211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}