{"id":"W1994225358","doi":"10.1016/j.bbrc.2012.02.038","title":"Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: Implications for biological assembly and inhibitor development","year":2012,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Gene isoform; Carbonic anhydrase; Isozyme; Bicarbonate; Chemistry; Biochemistry; Active site; Ligand (biochemistry); Enzyme; Crystal structure; Stereochemistry; Biophysics; Biology; Crystallography; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285079,0.0001950723,0.0002421077,0.0001022936,0.0002916433,0.0005658288,0.0004125886,0.0003681777,0.0007762412],"category_scores_gemma":[0.0003015536,0.0001360535,0.0001226921,0.0001802231,0.0002436588,0.0002254211,0.0001477121,0.00104517,0.0001985155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007753171,"about_ca_system_score_gemma":0.0008451287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004161491,"about_ca_topic_score_gemma":0.005331889,"domain_scores_codex":[0.9999616,0.000004488997,0.000002284566,0.00000718094,0.00001763386,0.000006806419],"domain_scores_gemma":[0.9999071,0.00001866112,0.0000210193,0.000004806098,0.00002106752,0.0000272583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001110048,0.0003449963,0.006951247,0.0003498141,0.00007587521,0.001527259,0.0005727998,0.01029966,0.9166023,0.02497302,0.01422648,0.02296661],"study_design_scores_gemma":[0.001273881,0.000757788,0.04208484,0.0001343133,0.0001831526,0.003667432,0.001162173,0.1794078,0.6366813,0.01059743,0.1239382,0.0001117065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776184,0.002927514,0.008809085,0.002015554,0.0002342616,0.00003592459,0.0009781811,0.0002172968,0.007163838],"genre_scores_gemma":[0.9760996,0.002607945,0.01072414,0.0003373511,0.00004893404,0.00003336875,0.003250018,0.00004437634,0.006854137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004161491,"threshold_uncertainty_score":0.008274496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0616170590235554,"score_gpt":0.3377837925454248,"score_spread":0.2761667335218694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}