{"id":"W1994287518","doi":"10.1016/s0022-1759(02)00027-3","title":"Selection by phage display of llama conventional VH fragments with heavy chain antibody VHH properties","year":2002,"lang":"en","type":"article","venue":"Journal of Immunological Methods","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"","keywords":"Panning (audio); Phage display; Antibody; Peptide library; Escherichia coli; Immunoglobulin light chain; Single-domain antibody; Molecular biology; Heavy chain; Chemistry; Oligonucleotide; Complementarity determining region; Biology; Computational biology; DNA; Peptide sequence; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002551521,0.0002771362,0.0003196378,0.0002105122,0.0002377452,0.0006332693,0.0003112039,0.0002912201,0.001601208],"category_scores_gemma":[0.0002603192,0.0002206339,0.0002187243,0.0002441741,0.0002008559,0.0001826243,0.0005357392,0.0008327708,0.0007011607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002742964,"about_ca_system_score_gemma":0.0001224263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004728603,"about_ca_topic_score_gemma":0.0008930461,"domain_scores_codex":[0.9997533,0.00004451316,0.00001209966,0.00003559111,0.00005892696,0.00009560631],"domain_scores_gemma":[0.9998052,0.0000719282,0.00002114435,0.00003295768,0.0000228985,0.00004603172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005663174,0.00002339814,0.00016328,0.000005817385,0.000001959967,0.00002671627,0.00001760465,0.0000312245,0.9988822,0.0000771367,0.00002561972,0.0006884101],"study_design_scores_gemma":[0.00001928471,0.0001560812,0.001985569,0.000003335852,0.00001303469,0.000227352,0.00003506871,0.001156972,0.9937108,0.00004169098,0.002645867,0.000005038904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910027,0.0002082929,0.00652389,0.00007149655,0.00002162756,0.00002860488,0.00009370407,0.00007006215,0.00197964],"genre_scores_gemma":[0.9917441,0.0001711734,0.003390971,0.0000713806,0.00001344151,0.00002449857,0.0003574772,0.00006285621,0.004163993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001601208,"threshold_uncertainty_score":0.00535661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05835380950607767,"score_gpt":0.3821389865912455,"score_spread":0.3237851770851679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}