{"id":"W1994331630","doi":"10.1182/blood-2007-11-125039","title":"CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"EIF4E; CCL5; PI3K/AKT/mTOR pathway; Cell biology; P70-S6 Kinase 1; Chemotaxis; Biology; Ribosomal protein s6; mTORC1; Chemokine; Molecular biology; Translation (biology); T cell; Messenger RNA; Signal transduction; Receptor; Biochemistry; Immunology; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001426454,0.0005499754,0.0002408538,0.0002962501,0.0003516789,0.0003465758,0.0001082588,0.000227646,0.001771013],"category_scores_gemma":[0.00009498009,0.0001025757,0.0003681844,0.0001553389,0.0002111964,0.0001982848,0.0001725233,0.0003534984,0.000426553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005566499,"about_ca_system_score_gemma":0.0003903513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222934,"about_ca_topic_score_gemma":0.002580984,"domain_scores_codex":[0.9998373,0.00002875818,0.00001617092,0.00003348904,0.00003074827,0.00005348783],"domain_scores_gemma":[0.9999329,0.000008509346,0.00002219005,0.000003902932,0.00001456859,0.00001799593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002146125,0.00003183348,0.0003583192,0.0001418777,0.000007327358,0.00007413925,0.00001278131,0.0001004109,0.9960786,0.0001943518,0.0001406924,0.002645094],"study_design_scores_gemma":[0.0000247025,0.000391258,0.009844704,0.00001528454,0.00002133367,0.0002034056,0.00004051293,0.00117548,0.9843053,0.00006599431,0.003902974,0.00000893153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745471,0.01235005,0.006065194,0.0004319578,0.0001712667,0.0001065172,0.00112844,0.0002514618,0.004948053],"genre_scores_gemma":[0.9868989,0.002914984,0.006358797,0.0001308033,0.00004900542,0.0000692408,0.000953069,0.00002486112,0.002600287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001771013,"threshold_uncertainty_score":0.005924582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02652208873692353,"score_gpt":0.2397380044682114,"score_spread":0.2132159157312879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}