{"id":"W1994332188","doi":"10.1371/journal.pone.0030375","title":"Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Key Research and Development Program of China; Central China Normal University; Novo Nordisk; Knut och Alice Wallenbergs Stiftelse; National Institute of Environmental Health Sciences; Karolinska Institutet; National Natural Science Foundation of China; Chinese Academy of Sciences; Ontario Genomics Institute; National Institutes of Health; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; Stiftelsen för Strategisk Forskning; Howard Hughes Medical Institute","keywords":"Arginine; Alternative splicing; SR protein; Binding site; Plasma protein binding; Biology; Biochemistry; RNA splicing; Effector; Chemistry; Cell biology; Molecular biology; Amino acid; Gene; Gene isoform","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002487423,0.0003943352,0.0005782637,0.0001680952,0.0004473161,0.0003806696,0.0007910195,0.0003743675,0.001170524],"category_scores_gemma":[0.0004705276,0.0002202564,0.000348334,0.0004410124,0.0002050221,0.0002151645,0.0002550935,0.001000775,0.0002456326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001521791,"about_ca_system_score_gemma":0.0006460539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009479304,"about_ca_topic_score_gemma":0.008376642,"domain_scores_codex":[0.9998215,0.00001932649,0.0000106564,0.00004276637,0.00007226002,0.00003358782],"domain_scores_gemma":[0.9998239,0.00003403033,0.00002888417,0.00001069464,0.00004676079,0.00005583393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001354541,0.000332399,0.007284961,0.0004142047,0.0001267358,0.00113966,0.0003633815,0.004650174,0.9692758,0.001445354,0.003202196,0.01041054],"study_design_scores_gemma":[0.0004598693,0.0005329691,0.05746495,0.00006578695,0.0002067672,0.002412634,0.0006666654,0.07683925,0.827583,0.0008550621,0.03280405,0.0001090614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897071,0.002797272,0.002922523,0.0003318609,0.0000463444,0.0000317261,0.001965535,0.0001369382,0.002060732],"genre_scores_gemma":[0.9806125,0.001316431,0.008002029,0.000114082,0.00001326722,0.00004100133,0.00665886,0.00006839642,0.003173509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009479304,"threshold_uncertainty_score":0.0188483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135544911278788,"score_gpt":0.2143214246516794,"score_spread":0.2007669335238006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}