{"id":"W1994332188","doi":"10.1371/journal.pone.0030375","title":"Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Key Research and Development Program of China; Central China Normal University; Novo Nordisk; Knut och Alice Wallenbergs Stiftelse; National Institute of Environmental Health Sciences; Karolinska Institutet; National Natural Science Foundation of China; Chinese Academy of Sciences; Ontario Genomics Institute; National Institutes of Health; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; Stiftelsen för Strategisk Forskning; Howard Hughes Medical Institute","keywords":"Arginine; Alternative splicing; SR protein; Binding site; Plasma protein binding; Biology; Biochemistry; RNA splicing; Effector; Chemistry; Cell biology; Molecular biology; Amino acid; Gene; Gene isoform","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006151252,0.0000793358,0.0001431518,0.00004535918,0.00002032303,0.000004264083,0.00003029973,0.0001210619,0.0000233235],"category_scores_gemma":[0.00002973907,0.00007976639,0.00001672669,0.00006519404,0.00005095354,0.000008896164,0.00004555429,0.00004061633,2.091807e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000639765,"about_ca_system_score_gemma":0.00001354814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004021413,"about_ca_topic_score_gemma":0.000003313576,"domain_scores_codex":[0.9994944,0.00002353772,0.0001506645,0.0001237356,0.0001007333,0.0001068686],"domain_scores_gemma":[0.999637,0.000005443951,0.0001348602,0.0001209414,0.000057164,0.00004456581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004385401,0.00006569031,0.01277374,0.0001000172,0.0001054504,4.766776e-8,0.00009468303,0.000002113583,0.9861967,0.00002322846,0.000004082646,0.000590414],"study_design_scores_gemma":[0.0003511703,0.00009835762,0.05497877,0.00004200973,0.00007893592,0.000003719998,0.00001233529,0.00006870255,0.9441426,0.000008251116,0.0001389201,0.00007623751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987954,0.0007704954,0.0001201233,0.00003701824,0.00003305147,0.0001308916,0.00007602492,0.000003784937,0.00003319247],"genre_scores_gemma":[0.9984299,0.0002775691,0.000690684,0.00000826065,0.0001519005,0.000001881326,0.0002929337,0.00001298628,0.0001338924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04220502,"threshold_uncertainty_score":0.3252779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135544911278788,"score_gpt":0.2143214246516794,"score_spread":0.2007669335238006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}