{"id":"W1994337442","doi":"10.1177/0269881111414451","title":"<i>CYP2C19</i> genotype predicts steady state escitalopram concentration in GENDEP","year":2011,"lang":"en","type":"article","venue":"Journal of Psychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"H. Lundbeck A/S; National Institute for Health and Care Research","keywords":"Escitalopram; CYP2C19; CYP2D6; Pharmacogenetics; Metabolite; Genotype; Pharmacology; Allele; Pharmacokinetics; Internal medicine; Pharmacogenomics; Biology; Medicine; Genetics; Antidepressant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003554753,0.0001565484,0.0003744164,0.0002118372,0.00002636893,0.000006693176,0.0001344974,0.0001162173,0.0007426359],"category_scores_gemma":[0.00003616328,0.0001241442,0.000100026,0.0001800199,0.00006787473,0.0002173692,0.00002046231,0.0004315216,0.00005176695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001473618,"about_ca_system_score_gemma":0.0001820324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001390989,"about_ca_topic_score_gemma":0.000007971431,"domain_scores_codex":[0.9984308,0.0001354269,0.0006588962,0.0001772499,0.0003076597,0.0002899111],"domain_scores_gemma":[0.998943,0.00005225013,0.0004478379,0.000136628,0.0001838541,0.0002363942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.023193,0.004987048,0.4040405,0.0001346003,0.000832306,0.005975441,0.007599543,0.00008177267,0.4791473,0.00005770107,0.03855246,0.03539835],"study_design_scores_gemma":[0.04572099,0.00566046,0.8880804,0.000223487,0.0006127399,0.001922063,0.0002684457,0.000186062,0.04530059,0.001189564,0.01053429,0.0003008498],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902025,0.00148285,0.0001716648,0.0003900744,0.001992707,0.0003567447,0.000005036047,0.00002290186,0.00537545],"genre_scores_gemma":[0.995953,0.0007755246,0.001858976,0.000840331,0.0002864229,0.000006885673,0.000003538486,0.00002285373,0.0002524194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.48404,"threshold_uncertainty_score":0.8131342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03547784942954203,"score_gpt":0.3259445998094181,"score_spread":0.2904667503798761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}