{"id":"W1994344707","doi":"10.1139/v06-072","title":"2005 Alfred Bader Award Lecture Diaminopimelate and lysine biosynthesis - An antimicrobial target in bacteria","year":2006,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Lipid II; Peptidoglycan; Chemistry; Biochemistry; Enzyme; Active site; Antimicrobial; Bacterial cell structure; Bacteria; Lantibiotics; Lysine; Aziridine; Nisin; Stereochemistry; Amino acid; Biology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001051619,0.0008420239,0.000505538,0.0007236421,0.0007532067,0.002110735,0.0008439143,0.003301595,0.07598425],"category_scores_gemma":[0.00105527,0.0002136588,0.0003867574,0.0003242516,0.000460994,0.001084437,0.0009268611,0.002388038,0.03437454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001845239,"about_ca_system_score_gemma":0.001719072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001333341,"about_ca_topic_score_gemma":0.002711856,"domain_scores_codex":[0.9994634,0.00005542748,0.00002609698,0.0001204314,0.0002458919,0.00008874264],"domain_scores_gemma":[0.9988016,0.00007727611,0.0000389592,0.00002896583,0.0004984246,0.0005548603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001290986,0.0000575138,0.0001961922,0.0001205946,0.00001180986,0.0001430182,0.00003134333,0.0001006649,0.001300008,0.003639108,0.9207823,0.07348839],"study_design_scores_gemma":[0.00002061218,0.00007754986,0.0004311482,0.00007935,0.000006510768,0.0002676347,0.00005147856,0.0001129959,0.0006392567,0.00092951,0.9973758,0.000008083402],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.006620988,0.1534463,0.004043679,0.3124003,0.2860078,0.0001962336,0.0006512215,0.0005279522,0.2361055],"genre_scores_gemma":[0.01998137,0.06117487,0.001862234,0.01718897,0.02486377,0.00006057912,0.0004063517,0.0001286079,0.8743334],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.07598425,"threshold_uncertainty_score":0.2541926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0030147249998846,"score_gpt":0.1801223373710077,"score_spread":0.1771076123711231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}