{"id":"W1994361647","doi":"10.3390/molecules16076092","title":"The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases","year":2011,"lang":"en","type":"review","venue":"Molecules","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Polyketide; Acyltransferase; Biosynthesis; Stereochemistry; Polyketide synthase; Chemistry; Dehydratase; Acyl carrier protein; Acyltransferases; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002418133,0.0004508886,0.0004470447,0.0002762395,0.000140913,0.0008287272,0.0004227226,0.0004113747,0.0007431934],"category_scores_gemma":[0.0002207299,0.0001581133,0.0002135511,0.0004464264,0.0003716815,0.000844611,0.0003384374,0.0006963982,0.0008078296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005617841,"about_ca_system_score_gemma":0.0004238777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003196744,"about_ca_topic_score_gemma":0.0003033428,"domain_scores_codex":[0.9998104,0.00002597901,0.00001642407,0.00005591508,0.00006511295,0.00002620507],"domain_scores_gemma":[0.9999036,0.00001820341,0.00003422625,0.000006169888,0.00002501905,0.00001280931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002737315,0.00004534773,0.001046838,0.005116751,0.0000773134,0.0009067193,0.0003293093,0.003410063,0.6870479,0.02649671,0.002551845,0.2726976],"study_design_scores_gemma":[0.00002424587,0.000328727,0.006577656,0.0004135437,0.0001028203,0.002489936,0.0001723835,0.001439979,0.4800882,0.01044243,0.4978248,0.00009529085],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1326062,0.8024071,0.02900961,0.0007436138,0.0007500995,0.00007535041,0.0006466546,0.0002941604,0.03346717],"genre_scores_gemma":[0.4699644,0.5064949,0.01083225,0.0004753192,0.000507676,0.00007419079,0.0008024466,0.00006650514,0.01078214],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0008287272,"threshold_uncertainty_score":0.004076064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04683019787876547,"score_gpt":0.2949600657200201,"score_spread":0.2481298678412547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}