{"id":"W1994383643","doi":"10.1038/nbt.1892","title":"Jury remains out on simple models of transcription factor specificity","year":2011,"lang":"en","type":"letter","venue":"Nature Biotechnology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Human Genome Research Institute; National Institutes of Health","keywords":"Jury; Simple (philosophy); Transcription factor; Computational biology; Factor (programming language); Biology; Computer science; Genetics; Gene; Political science; Law; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.00007570419,0.0004228126,0.0004736831,0.0002232411,0.00004879725,0.000009188447,0.0007048276,0.01085397,0.00003668501],"category_scores_gemma":[0.00003800487,0.0004023573,0.0002811588,0.00008403066,0.0002069867,0.00000235746,0.000123566,0.00285708,0.00001290478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005112769,"about_ca_system_score_gemma":0.00008212324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008254536,"about_ca_topic_score_gemma":0.00006399657,"domain_scores_codex":[0.9982238,0.00004922469,0.000387839,0.0007497328,0.0001848788,0.0004044727],"domain_scores_gemma":[0.9983924,0.00001082427,0.0003114914,0.001149383,0.0001025509,0.00003336763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000902524,0.00009483755,0.00001089523,0.0001622154,0.0001843851,0.00002943277,0.00004092759,0.00002205624,0.6273481,0.002228676,0.3677335,0.00205466],"study_design_scores_gemma":[0.0002820186,0.0004764569,0.00004467235,0.00002775414,0.00004001097,0.00001530079,0.00001068737,0.00009107396,0.3115243,0.003816299,0.6832466,0.0004247969],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7499496,0.00616745,0.01206951,0.2082505,0.004809559,0.002042863,0.006218242,0.0003693339,0.01012295],"genre_scores_gemma":[0.9172627,0.001800209,0.001768211,0.07288425,0.001729671,0.00002179664,0.003031234,0.0001603074,0.001341634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3158238,"threshold_uncertainty_score":0.9998428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01534078198552798,"score_gpt":0.2288067966941172,"score_spread":0.2134660147085892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}