{"id":"W1994383679","doi":"10.1110/ps.01701","title":"High‐resolution crystal structure of apolipoprotein(a) kringle IV type 7: Insights into ligand binding","year":2001,"lang":"en","type":"article","venue":"Protein Science","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Chemistry; Steric effects; Stereochemistry; Kringle domain; Lysine; Ligand (biochemistry); Binding site; Amino acid; Biochemistry; Receptor; Plasmin; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001907681,0.0001368087,0.0001230997,0.0001166694,0.0002369964,0.00003777476,0.0003731271,0.0001161818,0.00002075998],"category_scores_gemma":[0.0001702711,0.0001199562,0.00003700877,0.0005167903,0.0002762924,0.00002866909,0.0002284294,0.00009074648,0.000005884858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003381577,"about_ca_system_score_gemma":0.0001960445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001404395,"about_ca_topic_score_gemma":0.00003775397,"domain_scores_codex":[0.998721,0.00002711262,0.0001937447,0.0004161351,0.0003487665,0.0002932519],"domain_scores_gemma":[0.9992188,0.000002123557,0.0001246269,0.0003595842,0.0001877563,0.0001071244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005174166,0.00002355596,0.0000582483,0.0000163814,0.000004421925,0.000001930559,0.0000568256,0.00002646694,0.9980151,0.0009270911,0.00001846635,0.0007997864],"study_design_scores_gemma":[0.0001894761,0.0004043758,0.00006927165,0.00004297139,0.000003932813,0.000009535815,0.00002689123,0.0001089291,0.994504,0.00297859,0.001506216,0.0001557699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971257,0.0003676864,0.001607375,0.00003725629,0.0001832638,0.0004315813,0.000005348248,0.00001554432,0.0002261955],"genre_scores_gemma":[0.9955239,0.00002476123,0.004002568,0.0000309888,0.0002203214,0.00001423429,0.00001619467,0.00001176759,0.0001552355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003511044,"threshold_uncertainty_score":0.489167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008614096777997479,"score_gpt":0.2358226963361565,"score_spread":0.227208599558159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}