{"id":"W1994386407","doi":"10.1016/j.tiv.2009.08.014","title":"Characterization and hepatic differentiation of skin-derived precursors from adult foreskin by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development","year":2009,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Hepatocyte nuclear factor 4; Hepatocyte growth factor; Biology; Hepatocyte; Transdifferentiation; Hepatocyte nuclear factors; Cellular differentiation; Molecular biology; Cell biology; Stem cell; Transcription factor; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006712037,0.0001623386,0.0002289978,0.000076642,0.00006534372,0.00001099657,0.00006725192,0.0001659374,0.00000309748],"category_scores_gemma":[0.0001429844,0.0001592238,0.00002374117,0.00007225484,0.00004362527,0.000007449104,0.00006892379,0.0000623044,3.657741e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002606464,"about_ca_system_score_gemma":0.00002630979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004648234,"about_ca_topic_score_gemma":0.0001702959,"domain_scores_codex":[0.9990416,0.00009436745,0.0002795975,0.0003203828,0.00007625537,0.0001878584],"domain_scores_gemma":[0.9996379,0.00002702605,0.0001231418,0.00008993816,0.00007115919,0.00005085761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001580472,0.00005805297,0.06424037,0.0000157375,0.00004546275,0.000001072206,0.001864765,0.000001393223,0.9315524,0.000002840288,0.000005369234,0.002054548],"study_design_scores_gemma":[0.0003547874,0.0002530108,0.2963504,0.00001431087,0.00001461395,0.000001000203,0.00005347241,0.0000294201,0.7027925,0.00001634837,0.0000119515,0.000108233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974585,0.0001754416,0.001926502,0.00006150147,0.00006241965,0.0002570133,0.00004435626,0.00001003608,0.000004295889],"genre_scores_gemma":[0.9984416,0.0001041386,0.0008194558,0.0001439883,0.00004334821,0.00002328797,0.0003996969,0.00001175069,0.0000127597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.23211,"threshold_uncertainty_score":0.6492958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537869537061078,"score_gpt":0.2499792047243518,"score_spread":0.234600509353741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}